INT268446

Context Info Confidence 0.02 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.58 Pain Relevance 0

embryo development (Cdk5, Cdk5r1) cytoplasm (Cdk5, Cdk5r1) nucleus (Cdk5, Cdk5r1) plasma membrane (Cdk5, Cdk5r1) cell cycle (Cdk5, Cdk5r1) kinase activity (Cdk5, Cdk5r1)

Cdk5 (Mus musculus) Cdk5r1 (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 6 5.00 Central nervous system 4 5.00 tolerance 2 5.00 Enkephalin 1 5.00 Inflammatory response 1 5.00 Bile 1 5.00 metalloproteinase 1 5.00 Hippocampus 1 5.00 cva 1 5.00 substance P 1 5.00

Disease Link Frequency Relevance Heat Injury 3 98.00 Disease 40 86.28 Alzheimer's Dementia 5 82.56 Amyloid Plaque 4 51.36 Dementia 1 36.28 Neurodegenerative Disease 1 32.96 Atherosclerosis 17 29.32 Atherosclerotic Plaque 5 12.40 Age-related Macular Degeneration 10 5.00 Ocular Toxicity (including Many Sub-types) 7 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

CDK5 is inactive in its monomeric form and needs p35 for activation, but when cells undergo oxidative injury or treatment with A?

CDK5 Positive_regulation (needs) of p35 associated with injury

1) Confidence 0.02 Published 2009 Journal Microb Cell Fact Section Body Doc Link PMC2674406 Disease Relevance 0.58 Pain Relevance 0

General Comments

This test has worked.