INT269065

Context Info Confidence 0.66 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.12 Pain Relevance 0.04

transport (Cybb) mitochondrion (Cybb) Golgi apparatus (Cybb) endoplasmic reticulum (Cybb) intracellular (Cybb) cytoplasm (Cybb)

Anatomy Link Frequency brain 2 Il6 (Mus musculus) Cybb (Mus musculus)

Pain Link Frequency Relevance Heat imagery 6 83.20 GABAergic 9 50.00 Hippocampus 13 5.00 cytokine 9 5.00 Inflammation 6 5.00 interneuron 5 5.00 ketamine 4 5.00 long-term potentiation 3 5.00 anesthesia 3 5.00 Central nervous system 1 5.00

Disease Link Frequency Relevance Heat Aging 23 65.68 Cognitive Disorder 35 50.00 Stress 1 37.68 INFLAMMATION 6 5.00 Disease 6 5.00 Hypertension 2 5.00 Schizophrenia 2 5.00 Urological Neuroanatomy 2 5.00 Diabetes Mellitus 2 5.00 Frailty 2 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Consistent with a direct effect of IL-6 on Nox2 expression, direct systemic injection of IL-6 into mice increased Nox2 protein and activity, confirming the ability of peripheral IL-6 to mediate increased Nox2 expression and superoxide production in brain.

IL-6 Regulation (effect) of Gene_expression (expression) of Nox2 in brain

1) Confidence 0.66 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2678193 Disease Relevance 0.12 Pain Relevance 0.04

General Comments

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