INT269225

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Context Info
Confidence 0.58
First Reported 2009
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 4
Total Number 9
Disease Relevance 9.11
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (SNAI1) intracellular (SNAI1) cytoplasm (SNAI1)
Anatomy Link Frequency
stroma 6
lymph node 2
SNAI1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 24 97.24 Very High Very High Very High
palliative 9 88.08 High High
cytokine 3 13.76 Low Low
chemokine 3 5.00 Very Low Very Low Very Low
fibrosis 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 789 99.84 Very High Very High Very High
Metastasis 198 99.06 Very High Very High Very High
Ovarian Cancer 6 97.68 Very High Very High Very High
INFLAMMATION 24 97.24 Very High Very High Very High
Carcinoma 33 96.24 Very High Very High Very High
Endometroid Carcinoma 3 95.52 Very High Very High Very High
Skin Cancer 123 87.60 High High
Colorectal Cancer 15 87.08 High High
Adenocarcinoma 6 85.72 High High
Recurrence 33 83.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A range of possibilities may explain how Snail1 expression in the stroma, even at lower levels, decreases survival.
Negative_regulation (decreases) of Gene_expression (expression) of Snail1 in stroma
1) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2680015 Disease Relevance 0.81 Pain Relevance 0
The lymph node metastasis in this case was strikingly p63 negative, but displayed SNAI1 expression in only 10% of all tumor cells.
Negative_regulation (displayed) of Gene_expression (expression) of SNAI1 in lymph node associated with cancer and metastasis
2) Confidence 0.57 Published 2010 Journal BMC Clin Pathol Section Body Doc Link PMC2829523 Disease Relevance 0.78 Pain Relevance 0.09
However, at this level SNAI1 expression was observed in the majority (30/46; 65%) cases. 10 (22%) cases displayed SNAI1 expression at a level of ?
Negative_regulation (displayed) of Gene_expression (expression) of SNAI1
3) Confidence 0.57 Published 2010 Journal BMC Clin Pathol Section Body Doc Link PMC2829523 Disease Relevance 1.23 Pain Relevance 0.05
Some other examples of cells presenting Snail1 nuclear expression are also shown.
Negative_regulation (presenting) of Gene_expression (expression) of Snail1
4) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2680015 Disease Relevance 0.69 Pain Relevance 0.07
In these studies the association with survival was detected with Snail1 expression in the tumour whereas we found it with its presence in the stroma.
Negative_regulation (detected) of Gene_expression (expression) of Snail1 in stroma associated with cancer
5) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2680015 Disease Relevance 0.88 Pain Relevance 0
However, at this level SNAI1 expression was observed in the majority (30/46; 65%) cases. 10 (22%) cases displayed SNAI1 expression at a level of ?
Negative_regulation (observed) of Gene_expression (expression) of SNAI1
6) Confidence 0.41 Published 2010 Journal BMC Clin Pathol Section Body Doc Link PMC2829523 Disease Relevance 1.11 Pain Relevance 0.05
To examine the clinical impact of SNAI1 expression, the distribution of cases with Category 2 labeling and higher (?
Spec (examine) Negative_regulation (impact) of Spec (examine) Gene_expression (expression) of SNAI1
7) Confidence 0.41 Published 2010 Journal BMC Clin Pathol Section Body Doc Link PMC2829523 Disease Relevance 0.75 Pain Relevance 0
Two representative examples of SNAI1 expression in tumor cells are shown in Figure 1A and 1B.
Negative_regulation (examples) of Gene_expression (expression) of SNAI1 associated with cancer
8) Confidence 0.41 Published 2010 Journal BMC Clin Pathol Section Body Doc Link PMC2829523 Disease Relevance 1.62 Pain Relevance 0.03
Finally, in the group of cases with "rare/occasional" SNAI1 expression in tumor stroma, 2/15 corresponding tumors were negative, 6/15 had SNAI1 expression in <5% tumors cells and 7/15 were categorized as SNAI1-positive (?
Negative_regulation (had) of Gene_expression (expression) of SNAI1 in stroma associated with cancer
9) Confidence 0.36 Published 2010 Journal BMC Clin Pathol Section Body Doc Link PMC2829523 Disease Relevance 1.25 Pain Relevance 0

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