INT269322

Context Info Confidence 0.03 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0.18

cytosol (NOS1) nuclear envelope (TMPO) oxidoreductase activity (NOS1) chromosome (TMPO) cytoskeleton (NOS1) nucleus (TMPO)

TMPO (Homo sapiens) NOS1 (Homo sapiens)

Pain Link Frequency Relevance Heat agonist 84 100.00 bradykinin 1 100.00 b2 receptor 1 95.20 COX2 1 5.00 Angina 1 5.00

Disease Link Frequency Relevance Heat Increased Venous Pressure Under Development 3 16.52 Adhesions 1 9.28 Thrombosis 2 5.00 Hypertension 2 5.00 Stress 2 5.00 Apoptosis 1 5.00 Renal Disease 1 5.00 Injury 1 5.00 Cv General 3 Under Development 1 5.00 Asthma 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

NO regulation and synthesis via activation of the Ca2+ dependent eNOS or nNOS isozymes can occur in response to a diverse array of agonists that signal through GPCRs, including the widely documented bradykinin and muscarinic acetylcholine receptors signalling pathways, in addition to TP [70,80].

TP Positive_regulation (occur) of Positive_regulation (activation) of nNOS associated with agonist and bradykinin

1) Confidence 0.03 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.18

General Comments

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