INT269395

Context Info Confidence 0.39 First Reported 2007 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 1.84 Pain Relevance 0.12

small molecule metabolic process (NOS3) aging (NOS3) Golgi apparatus (NOS3) mitochondrion organization (NOS3) cytoplasm (NOS3) cytosol (NOS3)

NOS3 (Homo sapiens) NOS3 - E298D (1)

Pain Link Frequency Relevance Heat b2 receptor 1 87.92 bradykinin 1 81.52 agonist 84 78.72 Angina 2 5.00 COX2 1 5.00

Disease Link Frequency Relevance Heat Myocardial Infarction 65 100.00 Nicotine Addiction 19 99.84 Atherosclerosis 5 95.28 Increased Venous Pressure Under Development 4 86.72 Cardiovascular Disease 2 85.52 Obesity 9 72.28 Hypertension 11 71.32 Hyperlipidemia 6 54.24 Disease 3 46.52 Coronary Artery Disease 13 43.32

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The association between eNOS E298D polymorphism and MI is strongly affected by cigarette smoking.

Regulation (affected) of eNOS (E298D) Binding (association) of associated with nicotine addiction and myocardial infarction

1) Confidence 0.39 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2954842 Disease Relevance 1.84 Pain Relevance 0

While we have not been able to find any evidence for a direct interaction between eNOS and TP?

Regulation (direct) of eNOS Binding (interaction) of

2) Confidence 0.16 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.12

General Comments

This test has worked.