INT269561

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Context Info
Confidence 0.22
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 0
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (TMPO, RHOA) cell differentiation (RHOA) mitochondrion (RHOA)
nuclear envelope (TMPO) cell morphogenesis (RHOA) intracellular (RHOA)
TMPO (Homo sapiens)
RHOA (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 78 99.56 Very High Very High Very High
imagery 12 10.76 Low Low
Angina 6 5.00 Very Low Very Low Very Low
antagonist 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 18 46.72 Quite Low
Hypertension 24 5.00 Very Low Very Low Very Low
Targeted Disruption 24 5.00 Very Low Very Low Very Low
Thrombosis 18 5.00 Very Low Very Low Very Low
Atherosclerosis 18 5.00 Very Low Very Low Very Low
Disease 12 5.00 Very Low Very Low Very Low
Coronary Artery Disease 6 5.00 Very Low Very Low Very Low
Muscular Spasm 6 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 6 5.00 Very Low Very Low Very Low
Cv General 3 Under Development 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
in a concentration-dependent manner but had no effect on RhoA activation by TP?
TP Positive_regulation (activation) of RhoA
1) Confidence 0.22 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0
Similarly, SIN-1 also significantly impaired U46619-mediated RhoA activation by TP?
TP Positive_regulation (activation) of RhoA
2) Confidence 0.22 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0
Consistent with the latter data, the PGD2 analogue BW245C and the alternative NO donor FK409 also significantly impaired U46619-mediated RhoA activation (Fig. 3C) and cofilin phosphorylation (data not shown) by TP?
TP Positive_regulation (activation) of RhoA
3) Confidence 0.22 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0
From concentration-response studies, 10–100 nM U46619 was required for maximal RhoA activation by both TP?
TP Positive_regulation (activation) of RhoA
4) Confidence 0.15 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0
Consistent with this, the PGD2 receptor (DP) agonist BW245C also impaired RhoA activation by TP?
TP Positive_regulation (activation) of RhoA associated with agonist
5) Confidence 0.15 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0.12
-mediated [Ca2+]i mobilization and the G12/RhoGEF-dependent RhoA activation and cofilin phosphorylation by TP?
TP Positive_regulation (activation) of RhoA
6) Confidence 0.15 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0.12

General Comments

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