INT270046

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Context Info
Confidence 0.15
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.80
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ido1, Hmox1) oxidoreductase activity (Ido1, Hmox1) endoplasmic reticulum (Hmox1)
enzyme binding (Hmox1) signal transducer activity (Hmox1) cytoplasm (Ido1)
Ido1 (Mus musculus)
Hmox1 (Mus musculus)
Pain Link Frequency Relevance Heat
Multiple sclerosis 62 91.28 High High
Demyelination 12 88.24 High High
Endocannabinoid 7 51.04 Quite High
Inflammation 6 5.00 Very Low Very Low Very Low
rheumatoid arthritis 4 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
dexamethasone 2 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
Cannabinoid 2 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Demyelinating Disease 84 91.28 High High
Multiple Sclerosis 35 86.88 High High
Disorder Of Lipid Metabolism 4 25.00 Low Low
Toxicity 1 25.00 Low Low
Lipodystrophy 1 25.00 Low Low
Dementia 1 25.00 Low Low
Disease 9 5.00 Very Low Very Low Very Low
Autoimmune Disease 7 5.00 Very Low Very Low Very Low
INFLAMMATION 6 5.00 Very Low Very Low Very Low
Death 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The mechanism of action (MOA) is now known to involve induction of indoleamine 2,3-dioxygenase (IDO) and interleukin-10 (IL-10), where IL-10 requires subsequent heme oxygenase-1 (HMOX-1) induction.
IDO Positive_regulation (requires) of Positive_regulation (induction) of heme oxygenase-1
1) Confidence 0.15 Published 2009 Journal PPAR Research Section Abstract Doc Link PMC2683338 Disease Relevance 0.80 Pain Relevance 0.27

General Comments

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