INT270217

Context Info Confidence 0.03 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 1.63 Pain Relevance 0.81

cytosol (Ca2) extracellular space (Ca2) lyase activity (Ca2) cellular_component (C2) response to stress (Ca2) cytoplasm (Ca2)

Anatomy Link Frequency neuronal 2 C2 (Rattus norvegicus) Ca2 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Peripheral nerve injury 20 87.72 Eae 8 78.40 dorsal root ganglion 154 76.80 Neurotransmitter 2 65.52 Neuropathic pain 26 58.12 Brush evoked pain 38 53.80 Root ganglion neuron 2 50.00 Pain 16 46.84 agonist 10 21.44 Spinal cord 12 5.00

Disease Link Frequency Relevance Heat Nervous System Injury 88 87.72 Inflammatory Pain 2 78.40 Ganglion Cysts 156 76.80 Nociception 2 74.16 Neuropathic Pain 70 58.12 Pain 18 46.84 Injury 10 40.32 INFLAMMATION 4 5.00 Hyperalgesia 2 5.00

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Anatomy

Negation

Speculation

Pain term

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While cPLA2 is distributed throughout the cytoplasm in the normal condition, in response to a variety of extracellular stimuli, an increase in intracellular Ca2+ concentration promotes binding of Ca2+ to the C2 domain and then allows cPLA2 to translocate to the perinuclear region, including the nuclear envelope, Golgi apparatus and endoplasmic reticulum in non-neuronal cells [27-31].

C2 Binding (binding) of Ca2 in neuronal

1) Confidence 0.03 Published 2009 Journal Mol Pain Section Body Doc Link PMC2684092 Disease Relevance 0.79 Pain Relevance 0.39

While cPLA2 is distributed throughout the cytoplasm in the normal condition, in response to a variety of extracellular stimuli, an increase in intracellular Ca2+ concentration promotes binding of Ca2+ to the C2 domain and then allows cPLA2 to translocate to the perinuclear region, including the nuclear envelope, Golgi apparatus and endoplasmic reticulum in non-neuronal cells [27-31].

C2 Binding (binding) of Ca2 in neuronal

2) Confidence 0.03 Published 2009 Journal Mol Pain Section Body Doc Link PMC2684092 Disease Relevance 0.84 Pain Relevance 0.42

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