INT270431

Context Info Confidence 0.06 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.51 Pain Relevance 0.03

extracellular region (Gnrh1, APP) Golgi apparatus (APP) extracellular matrix organization (APP) DNA binding (APP) cytoplasm (APP) cytosol (APP)

Anatomy Link Frequency brain 1 Gnrh1 (Mus musculus) APP (Homo sapiens)

Pain Link Frequency Relevance Heat positron emission tomography 8 61.20 cINOD 8 5.00 Inflammation 7 5.00 Glutamate 7 5.00 nMDA receptor 4 5.00 Somatostatin 4 5.00 Nerve growth factor 3 5.00 cva 2 5.00 antagonist 2 5.00 Neurotransmitter 2 5.00

Disease Link Frequency Relevance Heat Disease 123 99.04 Targeted Disruption 7 88.16 Cognitive Disorder 28 83.76 Dementia 10 54.88 Frailty 6 29.04 Apoptosis 3 27.28 Neurodegenerative Disease 2 25.20 Stress 3 19.64 INFLAMMATION 8 5.00 Amyloid Plaque 7 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

AD patients show higher serum and brain levels of luteinizing hormone (LH), which facilitates APP processing through the amyloidogenic pathway [99].

luteinizing hormone Positive_regulation (facilitates) of APP in brain associated with disease

1) Confidence 0.06 Published 2009 Journal The Open Neurology Journal Section Body Doc Link PMC2684708 Disease Relevance 0.51 Pain Relevance 0.03

General Comments

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