INT270455

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Context Info
Confidence 0.39
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.66
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ptch1) extracellular region (Ptch1) plasma membrane (Ptch1)
Ptch1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 12 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 2 99.60 Very High Very High Very High
Retinal Neovascularization 2 99.16 Very High Very High Very High
Cancer 6 79.40 Quite High
Injury 14 52.88 Quite High
Burns 12 14.52 Low Low
Corneal Neovascularization 12 5.00 Very Low Very Low Very Low
Wound Healing 4 5.00 Very Low Very Low Very Low
Malignant Neoplastic Disease 4 5.00 Very Low Very Low Very Low
Bacterial Infection 2 5.00 Very Low Very Low Very Low
Necrosis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This report also shows that Shh activation is located upstream of VEGF in experimental retinal neovascularization under retinal hypoxic conditions because inhibition of the Shh pathway results in the reduction of VEGF level along with that of Patched-1 (Ptch1), a canonical Shh target.
Negative_regulation (inhibition) of Gene_expression (target) of Ptch1 associated with hypoxia and retinal neovascularization
1) Confidence 0.39 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2684749 Disease Relevance 0.33 Pain Relevance 0
This report also shows that Shh activation is located upstream of VEGF in experimental retinal neovascularization under retinal hypoxic conditions because inhibition of the Shh pathway results in the reduction of VEGF level along with that of Patched-1 (Ptch1), a canonical Shh target.
Negative_regulation (inhibition) of Gene_expression (target) of Patched-1 associated with hypoxia and retinal neovascularization
2) Confidence 0.39 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2684749 Disease Relevance 0.33 Pain Relevance 0

General Comments

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