INT270662

Context Info Confidence 0.32 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.51 Pain Relevance 0

extracellular space (Il2) extracellular region (Il2)

Anatomy Link Frequency telomere 1 Ctex (Mus musculus) Il2 (Mus musculus)

Pain Link Frequency Relevance Heat chemokine 7 5.00 Inflammation 5 5.00 Inflammatory response 2 5.00 Glutamate 2 5.00 diabetic neuropathy 2 5.00 member 8 1 5.00 adenocard 1 5.00 agonist 1 5.00 Crohn's disease 1 5.00 Arthritis 1 5.00

Disease Link Frequency Relevance Heat Diabetes Mellitus 154 95.84 Disease 8 93.04 Autoimmune Disease 15 62.00 INFLAMMATION 7 5.00 Diabetes Mellitus-type I 7 5.00 Renal Disease 5 5.00 Hyperglycemia 5 5.00 Genetic Predisposition To Disease 4 5.00 Sprains And Strains 4 5.00 Apoptosis 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Optimal Ctla expression is controlled by a locus (ctex) telomere on chromosome 1 together with the Idd3 (interleukin-2) gene upon CD3 activation of T cells [5].

ctex Regulation (controlled) of interleukin-2 in telomere

1) Confidence 0.32 Published 2008 Journal Current Genomics Section Body Doc Link PMC2685644 Disease Relevance 0.51 Pain Relevance 0

General Comments

This test has worked.