INT270996

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Context Info
Confidence 0.24
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.83
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (LTC4S) small molecule metabolic process (LTC4S) lyase activity (LTC4S)
endoplasmic reticulum (LTC4S) signal transducer activity (TBXA2R) lipid binding (LTC4S)
TBXA2R (Homo sapiens)
LTC4S (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 31 97.24 Very High Very High Very High
Inflammation 5 64.80 Quite High
antagonist 5 5.00 Very Low Very Low Very Low
cINOD 3 5.00 Very Low Very Low Very Low
COX2 2 5.00 Very Low Very Low Very Low
adenocard 1 5.00 Very Low Very Low Very Low
Antihistamine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Asthma 69 97.52 Very High Very High Very High
INFLAMMATION 5 64.80 Quite High
Pressure And Volume Under Development 42 5.00 Very Low Very Low Very Low
Urticaria 20 5.00 Very Low Very Low Very Low
Hypersensitivity 4 5.00 Very Low Very Low Very Low
Rhinitis 3 5.00 Very Low Very Low Very Low
Nasal Polyps 2 5.00 Very Low Very Low Very Low
Genetic Predisposition To Disease 2 5.00 Very Low Very Low Very Low
Hypersensitivity Pneumonitis 1 5.00 Very Low Very Low Very Low
Drug Hypersensitivity 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TBXA2R is a receptor for a potent bronchoconstrictor, thromboxane A2 (TBXA2), and a TBXA2R + 795T > C polymorphism could augment the bronchoconstrictive response to inhaled aspirin, possibly contributing to AIA development in the Korean population.28 The effect of increased TBXA2 production in the pathogenesis of AIA could be explained by the fact that oral aspirin administration uncouples the TBXA2-dependent negative feedback mechanisms, which may, in turn, increase the production of Cys-LTs.29 The TBXA2-dependent regulation of LTC4S activity may be an important pathophysiological mechanism in AIA.


TBXA2 Regulation (regulation) of LTC4S associated with asthma and aspirin
1) Confidence 0.24 Published 2006 Journal Yonsei Medical Journal Section Body Doc Link PMC2687575 Disease Relevance 0.83 Pain Relevance 0.13

General Comments

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