INT271024

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Context Info
Confidence 0.05
First Reported 2006
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.07
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (RYR1) transmembrane transport (RYR1) cytoplasm (RYR1)
Anatomy Link Frequency
myocytes 2
heart 2
RYR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
addiction 2 73.80 Quite High
Central nervous system 2 36.12 Quite Low
antagonist 2 11.28 Low Low
action potential duration 7 5.00 Very Low Very Low Very Low
Angina 3 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
sodium channel 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Bioavailability 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypertrophy 3 98.38 Very High Very High Very High
Myocardial Infarction 6 98.04 Very High Very High Very High
Coronary Artery Disease 9 97.74 Very High Very High Very High
Heart Rate Under Development 25 92.16 High High
Congenital Anomalies 2 85.76 High High
Arrhythmias 2 Under Development 111 85.28 High High
Arrhythmia Under Development 16 67.20 Quite High
Stroke 2 59.04 Quite High
Cv Unclassified Under Development 4 57.08 Quite High
Sudden Death 1 52.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, a significant reduction in ryanodine receptor binding was also observed in primary IOOA.
Negative_regulation (reduction) of ryanodine receptor Binding (binding) of
1) Confidence 0.05 Published 2006 Journal Yonsei Medical Journal Section Body Doc Link PMC2687630 Disease Relevance 0.09 Pain Relevance 0
However, other investigators have reported that the inactivation of Ca2+-ATPase is closely related with ischemic heart disease, heart failure, and hypertrophy of cardiac muscle; thus, as the intracellular Ca2+ concentration increases, the concentration of ryanodine receptor decreases, and in some cases, down regulation has been found to be associated with the decreased expression of its mRNA.23,24
Negative_regulation (decreases) of ryanodine receptor Binding (concentration) of in heart associated with hypertrophy, coronary artery disease and myocardial infarction
2) Confidence 0.04 Published 2006 Journal Yonsei Medical Journal Section Body Doc Link PMC2687630 Disease Relevance 0.29 Pain Relevance 0
In addition, it blocks the intracellular interaction between Ca2+ and the ryanodine receptor; new data presents flecainide as a novel strategy in preventing diastolic Ca2+ waves that result in triggered arrhythmias.80 In ventricular myocytes isolated from a catecholaminergic polymorphic ventricular tachycardia mouse model, flecainide inhibited cardiac ryandodine receptor channels by open-state blockade, significantly reducing the spark Ca2+ mass without causing any compensatory increases in the sarcoplasmic reticulum Ca2+ content.
Negative_regulation (blocks) of ryanodine receptor Binding (interaction) of in myocytes associated with heart rate under development
3) Confidence 0.01 Published 2011 Journal Europace Section Body Doc Link PMC3024037 Disease Relevance 0.69 Pain Relevance 0.04

General Comments

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