INT271025

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Context Info
Confidence 0.03
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.70
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Car2, Casq1) cytosol (Car2) mitochondrion (Casq1)
extracellular space (Car2) lyase activity (Car2) Golgi apparatus (Casq1)
Anatomy Link Frequency
muscle 1
reticulum 1
Car2 (Mus musculus)
Casq1 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 2 62.92 Quite High
Central nervous system 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 8 72.48 Quite High
Eye Disease 4 71.12 Quite High
Muscle Disease 2 70.88 Quite High
Frailty 4 66.68 Quite High
Paralysis 10 62.20 Quite High
Heart Disease 2 60.80 Quite High
Malignant Hyperthermia 2 54.16 Quite High
Myasthenia Gravis 2 52.24 Quite High
Paresis 6 47.56 Quite Low
Hypertrophy 2 13.12 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Calsequestrin is a Ca2+ storage protein that binds Ca2+ within the lumen of the sarcoplasmic reticulum.
Ca2 Binding (binds) of Calsequestrin in reticulum
1) Confidence 0.03 Published 2006 Journal Yonsei Medical Journal Section Body Doc Link PMC2687630 Disease Relevance 0.34 Pain Relevance 0.03
These include ryanodine receptor, a Ca2+ release channel which participates in Ca2+ release from sarcoplasmic reticulum into muscle cells, Ca2+-ATPase, which drives Ca2+ uptake, and calsequestrin that binds with Ca2+.8-11 Thus, since Ca2+ uptake by the sarcoplasmic reticulum and Ca2+ release from the sarcoplasmic reticulum play key roles in the regulation of Ca2+ concentrations in muscle cells, the above proteins are important elements in studies on the mechanisms of muscle contraction and relaxation.
Ca2 Binding (binds) of calsequestrin in muscle
2) Confidence 0.02 Published 2006 Journal Yonsei Medical Journal Section Body Doc Link PMC2687630 Disease Relevance 0.36 Pain Relevance 0

General Comments

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