INT271499

Context Info Confidence 0.66 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0.62 Pain Relevance 0.24

extracellular space (Tnfsf15) plasma membrane (Tnfsf15)

Anatomy Link Frequency lymphocytes 1 Tnfsf15 (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 20 98.16 Crohn's disease 24 95.08 member 8 2 64.72 Arthritis 14 5.00 spinal inflammation 14 5.00 psoriasis 6 5.00 rheumatoid arthritis 6 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 12 98.16 Disease 36 95.08 Necrosis 2 63.32 Cancer 2 62.96 Spondylarthropathies 4 12.08 Inflammatory Bowel Disease 14 5.00 Low Back Pain 14 5.00 Seronegative Spondarthritis 8 5.00 Uveitis 6 5.00 Arthritis 6 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

A full re-sequencing of all exons, 1st and 3rd introns, and additional intronic boundaries of the TNFSF15 gene in several patients and controls did not reveal unmatched variations either (data not shown).

Gene_expression (boundaries) of TNFSF15

1) Confidence 0.66 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2689651 Disease Relevance 0.25 Pain Relevance 0.09

Its product, TNFSF15, also called TLA1, is implicated in the modulation of T-helper 17 lymphocytes activation [32], the number of which has been shown to be increased in patients with SpA [34].

Gene_expression (product) of TNFSF15 in lymphocytes

2) Confidence 0.59 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2689651 Disease Relevance 0.38 Pain Relevance 0.15

General Comments

This test has worked.