INT27155

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Context Info
Confidence 0.36
First Reported 1985
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 1.61
Pain Relevance 1.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (F12) extracellular space (F12) extracellular region (F12)
Anatomy Link Frequency
endothelial cells 3
blood 2
plasma 1
F12 (Mus musculus)
Pain Link Frequency Relevance Heat
opiate 1 100.00 Very High Very High Very High
Angina 2 92.20 High High
Pain 7 91.92 High High
bradykinin 18 85.80 High High
anesthesia 1 63.72 Quite High
Inflammation 3 50.00 Quite Low
aspirin 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pox Virus Infection 3 95.84 Very High Very High Very High
Cv General 3 Under Development 1 92.20 High High
Pain 7 91.92 High High
Hypersensitivity 6 90.84 High High
Hemorrhage 3 85.20 High High
Pressure And Volume Under Development 3 68.48 Quite High
Hyperlipidemia 2 63.80 Quite High
Disorder Of Lipid Metabolism 1 60.84 Quite High
Diabetes Mellitus 3 58.48 Quite High
Thrombosis 61 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Characterization of factor XII Tenri, a rare CRM-negative factor XII deficiency.
factor XII Binding (Characterization) of
1) Confidence 0.36 Published 2004 Journal Ann. Clin. Lab. Sci. Section Title Doc Link 15228238 Disease Relevance 0.09 Pain Relevance 0.09
A measure of FXIIa in citrated plasma was obtained by enzyme linked immunosorbent assay (ELISA methodology), using a specific monoclonal capture antibody (Mab 2/215) with no detectable recognition of FXII or FXIIa-C1 inhibitor complexes [33].
FXII Neg (no) Binding (recognition) of in plasma
2) Confidence 0.35 Published 2010 Journal Thromb J Section Body Doc Link PMC2871266 Disease Relevance 0.43 Pain Relevance 0
Sulfosphingolipids (sulfogalactosylceramide) may be involved in sodium transport, interaction of opiates with their receptors, activation of oxygen radical generating system, and blood coagulation Factor XII.
Factor XII Binding (interaction) of in blood associated with opiate
3) Confidence 0.32 Published 1985 Journal Mol. Cell. Biochem. Section Abstract Doc Link 2580222 Disease Relevance 0 Pain Relevance 0.10
[Anesthetic management of a patient with blood coagulation factor XII deficiency].
factor XII Binding (management) of in blood
4) Confidence 0.27 Published 2001 Journal Masui Section Title Doc Link 11424474 Disease Relevance 0.23 Pain Relevance 0.06
Factor XII (FXII) and high molecular weight kininogen (HK), two critical constituents of the plasma K-K cascade, bind to endothelial cells, and bound FXII is autoactivated in the presence of zinc ions.
FXII Binding (bound) of in endothelial cells
5) Confidence 0.14 Published 1998 Journal Biochem. Pharmacol. Section Abstract Doc Link 9719471 Disease Relevance 0.26 Pain Relevance 0.22
Factor XII (FXII) and high molecular weight kininogen (HK), two critical constituents of the plasma K-K cascade, bind to endothelial cells, and bound FXII is autoactivated in the presence of zinc ions.
FXII Binding (bind) of in endothelial cells
6) Confidence 0.14 Published 1998 Journal Biochem. Pharmacol. Section Abstract Doc Link 9719471 Disease Relevance 0.28 Pain Relevance 0.22
We have investigated the effects of Neurotropin on the interactions of FXII and HK with endothelial cells.
FXII Binding (interactions) of in endothelial cells
7) Confidence 0.10 Published 1998 Journal Biochem. Pharmacol. Section Abstract Doc Link 9719471 Disease Relevance 0.25 Pain Relevance 0.23
The KKS encompasses coagulation factor XII (FXII), the complex of prekallikrein (PK) and high molecular weight kininogen (HK).
FXII Binding (encompasses) of
8) Confidence 0.07 Published 2009 Journal Cardiovascular & hematological agents in medicinal chemistry Section Abstract Doc Link 19689262 Disease Relevance 0.07 Pain Relevance 0.29

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