INT271570

From wiki-pain
Revision as of 21:32, 23 September 2012 by Daniel (Talk | contribs)

(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to: navigation, search
Context Info
Confidence 0.65
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 21
Total Number 24
Disease Relevance 11.49
Pain Relevance 1.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
poly 1
muscle 1
skeletal muscle 1
alveolar macrophages 1
immune system 1
MIR1-1 (Homo sapiens)
Pain Link Frequency Relevance Heat
dexamethasone 9 96.92 Very High Very High Very High
tolerance 52 94.96 High High
endometriosis 145 93.24 High High
Inflammatory response 18 92.88 High High
rheumatoid arthritis 9 90.32 High High
psoriasis 9 84.40 Quite High
Inflammation 185 80.16 Quite High
corticosteroid 180 69.88 Quite High
chemokine 9 67.36 Quite High
cytokine 9 66.76 Quite High
Disease Link Frequency Relevance Heat
Pancreatic Cancer 56 99.78 Very High Very High Very High
Cancer 744 99.16 Very High Very High Very High
Myeloid Leukemia 12 98.84 Very High Very High Very High
Solid Tumor 9 98.80 Very High Very High Very High
Chronic Lymphoid Leukemia 29 98.44 Very High Very High Very High
Adenocarcinoma 12 98.44 Very High Very High Very High
Endometriosis 165 96.48 Very High Very High Very High
Disease 154 95.36 Very High Very High Very High
Impaired Glucose Tolerance 52 94.96 High High
Diabetes Mellitus 318 93.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A hub miRNA may show homogeneous or heterogeneous expression pattern in multiple cancer types.
Gene_expression (expression) of miR associated with cancer
1) Confidence 0.65 Published 2010 Journal Silenc Section Body Doc Link PMC2835996 Disease Relevance 1.17 Pain Relevance 0.03
Patients with high expression of either miR-155, miR-17-3p, miR-106a, miR-93 or miR-21 and low expression of either let-7a-2, let-7b or miR-145 were found to have a significantly worse prognosis.
Gene_expression (expression) of miR
2) Confidence 0.58 Published 2010 Journal Silenc Section Body Doc Link PMC2835996 Disease Relevance 0.96 Pain Relevance 0
For example, overexpression of the miR-17-92 cluster is thought to influence tumour progression [18], and is controlled by the transcription factor c-myc [19].
Gene_expression (overexpression) of miR associated with cancer
3) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2690402 Disease Relevance 1.48 Pain Relevance 0.17
This analysis revealed that miR-92, miR-26a, miR-200c, miR-16, let-7b, miR-125a, and miR-125b were the most highly expressed in human airway tissue, having levels more than 70-fold higher than the average miRNA and contributing 55.5% of the total mRNA detected in airway biopsies.
Gene_expression (expressed) of miR-1
4) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2690402 Disease Relevance 0.08 Pain Relevance 0
It has been observed in pancreatic cancer that high expression of miR-196a-2 and miR-219 can cause of a lower survival of the patients (14.3 months and 13.6 months) than the low expression (26.5 months and 23.8 months) [38].
Gene_expression (expression) of miR associated with pancreatic cancer
5) Confidence 0.58 Published 2010 Journal Silenc Section Body Doc Link PMC2835996 Disease Relevance 0.84 Pain Relevance 0
This analysis revealed that miR-92, miR-26a, miR-200c, miR-16, let-7b, miR-125a, and miR-125b were the most highly expressed in human airway tissue, having levels more than 70-fold higher than the average miRNA and contributing 55.5% of the total mRNA detected in airway biopsies.
Gene_expression (expressed) of miR-1
6) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2690402 Disease Relevance 0.08 Pain Relevance 0
This analysis revealed that miR-92, miR-26a, miR-200c, miR-16, let-7b, miR-125a, and miR-125b were the most highly expressed in human airway tissue, having levels more than 70-fold higher than the average miRNA and contributing 55.5% of the total mRNA detected in airway biopsies.
Gene_expression (expressed) of miR
7) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2690402 Disease Relevance 0.08 Pain Relevance 0
For example, overexpression of the miR-17-92 cluster is thought to influence tumour progression [18], and is controlled by the transcription factor c-myc [19].
Gene_expression (overexpression) of miR-1 associated with cancer
8) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2690402 Disease Relevance 1.48 Pain Relevance 0.17
This analysis revealed that miR-92, miR-26a, miR-200c, miR-16, let-7b, miR-125a, and miR-125b were the most highly expressed in human airway tissue, having levels more than 70-fold higher than the average miRNA and contributing 55.5% of the total mRNA detected in airway biopsies.
Gene_expression (expressed) of miR
9) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2690402 Disease Relevance 0.08 Pain Relevance 0
In [34], it has been shown that miR-181a family miRNAs are expressed at relatively low levels in AML.
Gene_expression (expressed) of miR associated with myeloid leukemia
10) Confidence 0.58 Published 2010 Journal Silenc Section Body Doc Link PMC2835996 Disease Relevance 1.40 Pain Relevance 0
Three miRNAs, miR-375, miR-449 and miR-200c were specifically expressed only in the airway samples.
Gene_expression (expressed) of miR
11) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2690402 Disease Relevance 0 Pain Relevance 0
Expression profiling of human airway biopsies revealed several highly expressed miRNAs, including miR-92, miR-200c, miR-26a, miR-16, let-7b, miR-125a and miR-125b, which together comprised 55.5% of the total miRNA species analysed.
Gene_expression (expressed) of miR
12) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2690402 Disease Relevance 0.42 Pain Relevance 0.30
The most prominent cell type was alveolar macrophages, which possessed a high expression of several miRNAs including miR-223 and miR-146b, further emphasising how migratory cells (as well as resident cells) contribute to the overall miRNA expression profile within a given tissue.
Gene_expression (expression) of miR in alveolar macrophages
13) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2690402 Disease Relevance 0.25 Pain Relevance 0.12
Over-expression of miR-1 [55] or miR-206 [86] in mouse myoblasts accelerates differentiation into myotubes whereas over-expression of miR-133 promotes proliferation [55].
Gene_expression (expression) of miR-1 in myotubes
14) Confidence 0.09 Published 2010 Journal Genome Med Section Body Doc Link PMC2847700 Disease Relevance 0.49 Pain Relevance 0
However, evidence of distinct binding proteins that modulate processing of pri-miRNA to mature miRNA [92] has emerged and we clearly demonstrate that expression of miR-1 and miR-133a are not co-regulated in vivo in human skeletal muscle.
Gene_expression (expression) of miR-1 in skeletal muscle
15) Confidence 0.09 Published 2010 Journal Genome Med Section Body Doc Link PMC2847700 Disease Relevance 0.26 Pain Relevance 0
Several groups have used microarray data to examine the expression changes when a single miRNA changes, and we used the mean absolute expression approach described recently by Arora and Simpson [49] and also the tissue-centric approach described by Sood et al. [50] to determine whether we could detect shifts in the average expression of mRNA targets of the muscle-specific miRNAs (miR-1, miR-133a/b and miR-206, collectively known as 'myomirs') in human skeletal muscle.
Gene_expression (expression) of miR-1 in muscle
16) Confidence 0.07 Published 2010 Journal Genome Med Section Body Doc Link PMC2847700 Disease Relevance 0 Pain Relevance 0
ANOVA indicated that miR-133a (F = 11.8, P < 0.0001) was significantly different between the three groups, miR-206 expression more modestly altered (F = 4.5, P = 0.02) and miR-1 and miR-133b were unchanged (Figure 2c).
Gene_expression (expression) of miR-1
17) Confidence 0.07 Published 2010 Journal Genome Med Section Body Doc Link PMC2847700 Disease Relevance 0.74 Pain Relevance 0.05
Recently, Kim and Bartel (40) tested the effect of 67 pDSPs altering target sites for miR-1/206, miR-133 and miR-122 in the 3?
Gene_expression (/) of miR-1
18) Confidence 0.05 Published 2010 Journal Nucleic Acids Research Section Body Doc Link PMC2808989 Disease Relevance 0.08 Pain Relevance 0
-UTR of the ovine MSTN gene that causes increased muscle mass by creating an illegitimate target site for coexpressed miR-1 and miR-206 (1), and the report of >10 associations of polymorphisms in miRNA target sites (poly-miRTS) with human disease [reviewed in (2)], (ii) the identification of mutations in the seed region of human miR-96 responsible for nonsyndromic progressive hearing loss (3,4) and (iii) the identification of DICER1 mutations in familial pleuropulmonary blastoma (5).
Gene_expression (coexpressed) of miR-1 in poly associated with deafness, blastoma and disease
19) Confidence 0.04 Published 2010 Journal Nucleic Acids Research Section Body Doc Link PMC2808989 Disease Relevance 0.27 Pain Relevance 0
MiRNA expression is tissue- and cell-specific [30–33].
Gene_expression (expression) of MiRNA
20) Confidence 0.01 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2837904 Disease Relevance 0.58 Pain Relevance 0.03

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox