INT271902

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Context Info
Confidence 0.12
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.08
Pain Relevance 0.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Jun) endosome (KCNK1) nucleus (Jun)
plasma membrane (KCNK1) DNA binding (Jun) transcription factor binding (Jun)
KCNK1 (Homo sapiens)
Jun (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 5 100.00 Very High Very High Very High
potassium channel 1 100.00 Very High Very High Very High
alcohol 100 95.08 Very High Very High Very High
cytokine 1 81.76 Quite High
Central nervous system 1 81.52 Quite High
addiction 63 75.20 Quite High
Nucleus accumbens 3 15.44 Low Low
gABA 9 5.00 Very Low Very Low Very Low
Dopamine 9 5.00 Very Low Very Low Very Low
withdrawal 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Alcohol Addiction 73 75.20 Quite High
Urological Neuroanatomy 2 16.96 Low Low
Drug Dependence 3 14.60 Low Low
Flushing 3 5.00 Very Low Very Low Very Low
Mental Disorders 3 5.00 Very Low Very Low Very Low
Disease 3 5.00 Very Low Very Low Very Low
Adhesions 2 5.00 Very Low Very Low Very Low
Cirrhosis 2 5.00 Very Low Very Low Very Low
Syndrome 2 5.00 Very Low Very Low Very Low
Apoptosis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Of them, Twik-1, coding for a potassium channel, was associated with tolerance, and JunB and Nur77, members of an immediate early gene family and of the nuclear receptor family respectively, had an increased expression that persisted a long time after alcohol ingestion [73].
Twik-1 Binding (associated) of immediate early associated with tolerance, potassium channel and alcohol
1) Confidence 0.12 Published 2008 Journal Current Genomics Section Body Doc Link PMC2691669 Disease Relevance 0.08 Pain Relevance 0.53

General Comments

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