INT271978

Context Info Confidence 0.00 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.54 Pain Relevance 0

nucleus (Racgap1, Mtor) cytoplasm (Racgap1, Mtor) cell differentiation (Racgap1) mitochondrion (Mtor) transport (Racgap1) embryo development (Racgap1)

Racgap1 (Mus musculus) Mtor (Mus musculus)

Pain Link Frequency Relevance Heat cerebral cortex 1 5.00 transdermal 1 5.00 adenocard 1 5.00 Angina 1 5.00

Disease Link Frequency Relevance Heat Tuberous Sclerosis 11 88.64 Hamartoma 8 85.80 Cancer 20 84.56 Disease 21 61.92 Angiomyolipoma 12 5.00 Lymphangioleiomyomatosis 11 5.00 Convulsion 9 5.00 Anaplastic Astrocytoma 6 5.00 Epilepsy 6 5.00 Polycystic Kidney Disease 6 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

TSC1/2 genes play a fundamental role in the regulation of phosphoinositide 3-kinase (PI3K) signalling pathway, inhibiting the mammalian target of rapamycin (mTOR) through activation of the GTPase activity of Rheb.

Positive_regulation (activation) of GTPase Regulation (target) of mTOR

1) Confidence 0.00 Published 2008 Journal Current Genomics Section Abstract Doc Link PMC2691673 Disease Relevance 0.54 Pain Relevance 0

General Comments

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