INT271991

Context Info Confidence 0.23 First Reported 2008 Last Reported 2008 Negated 1 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.15 Pain Relevance 0

cytosol (Tsc1, Tsc2) protein complex (Tsc1, Tsc2) cytoplasm (Tsc1, Tsc2) signal transduction (Tsc2) Golgi apparatus (Tsc2) nucleus (Tsc2)

Tsc1 (Mus musculus) Tsc2 (Mus musculus)

Pain Link Frequency Relevance Heat cerebral cortex 1 5.00 transdermal 1 5.00 adenocard 1 5.00 Angina 1 5.00

Disease Link Frequency Relevance Heat Cancer 20 77.20 Tuberous Sclerosis 11 50.00 Stress 2 43.44 Hamartoma 8 37.00 Death 4 35.60 Apoptosis 3 31.44 Disease 21 5.00 Angiomyolipoma 12 5.00 Lymphangioleiomyomatosis 11 5.00 Convulsion 9 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Neither tuberin nor hamartin are in a complex with Skp2 and tuberin does not affect Skp2 protein levels, and the SCFSkp2 ubiquitin ligase does not regulate tuberin stability.

hamartin Neg (not) Regulation (regulate) of tuberin

1) Confidence 0.23 Published 2008 Journal Current Genomics Section Body Doc Link PMC2691673 Disease Relevance 0.15 Pain Relevance 0

General Comments

This test has worked.