INT272008

Context Info Confidence 0.01 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.32 Pain Relevance 0

cytoplasm (Tsc1, HERC1) cytosol (Tsc1, HERC1) transport (HERC1) Golgi apparatus (HERC1) intracellular (HERC1) embryo development (Tsc1)

Tsc1 (Mus musculus) HERC1 (Homo sapiens)

Pain Link Frequency Relevance Heat cerebral cortex 1 5.00 transdermal 1 5.00 adenocard 1 5.00 Angina 1 5.00

Disease Link Frequency Relevance Heat Papillomavirus Infection 1 90.08 Syndrome 2 83.40 Polycystic Kidney Disease 6 76.80 Cancer 20 67.04 Tuberous Sclerosis 11 50.00 Disease 21 44.00 Angiomyolipoma 12 5.00 Lymphangioleiomyomatosis 11 5.00 Convulsion 9 5.00 Hamartoma 8 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Hamartin stabilizes tuberin by inhibiting its interaction with the HERC1 ubiquitin ligase [38].

Hamartin Negative_regulation (inhibiting) of HERC1 ubiquitin ligase Binding (interaction) of

1) Confidence 0.01 Published 2008 Journal Current Genomics Section Body Doc Link PMC2691673 Disease Relevance 0.32 Pain Relevance 0

General Comments

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