INT272056

Context Info Confidence 0.10 First Reported 2007 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 3 Disease Relevance 3.58 Pain Relevance 0.10

small molecule metabolic process (NEU3) hydrolase activity, acting on glycosyl bonds (NEU3) plasma membrane (NEU3) carbohydrate metabolic process (NEU3)

NEU3 (Homo sapiens)

Pain Link Frequency Relevance Heat headache 3 78.60 withdrawal 1 50.68 Central nervous system 2 49.44 Inflammation 4 35.32 cytokine 6 34.64 cva 2 23.28 Bioavailability 1 12.96 aspirin 2 5.00 chemokine 2 5.00 depression 1 5.00

Disease Link Frequency Relevance Heat Influenza Virus Infection 478 100.00 Infection 32 95.72 Influenza In Birds 18 93.44 Sprains And Strains 91 92.88 Critical Illness 4 86.76 Adult Respiratory Distress Syndrome 1 84.44 Diarrhoea 2 79.84 Vomiting 4 79.32 Headache 3 78.60 Fever 11 76.52

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Neuraminidase is an enzyme expressed on the surface of influenza A and B that is essential for release of newly formed viruses from an infected cell.

Gene_expression (expressed) of Neuraminidase associated with influenza virus infection

1) Confidence 0.10 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2692119 Disease Relevance 1.04 Pain Relevance 0.03

Currently available antiviral therapy against influenza targets either the influenza M2 protein (adamantanes) or neuraminidase (neuraminidase inhibitors).

Gene_expression (targets) of neuraminidase associated with influenza virus infection

2) Confidence 0.07 Published 2009 Journal The Yale Journal of Biology and Medicine Section Body Doc Link PMC2794489 Disease Relevance 1.90 Pain Relevance 0.08

In humans, however, only three hemagglutinin proteins (H1, H2, and H3) and two neuraminidase proteins (N1 and N2) have been detected in epidemics and pandemics since 1900.

Gene_expression (detected) of neuraminidase

3) Confidence 0.04 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2692112 Disease Relevance 0.63 Pain Relevance 0

General Comments

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