INT272468

Context Info Confidence 0.40 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.40 Pain Relevance 0

cell differentiation (Mef2a) nucleus (Mef2a) DNA binding (Mef2a)

Anatomy Link Frequency muscle cells 1 Mef2a (Mus musculus)

Pain Link Frequency Relevance Heat Kinase C 2 5.00 tolerance 1 5.00 abdominal pain 1 5.00

Disease Link Frequency Relevance Heat Myotonic Dystrophy 8 75.00 Cataract 4 55.44 Arrhythmias 2 Under Development 1 55.00 Hypopituitarism 11 53.88 Frailty 3 53.48 Disease 13 5.00 Targeted Disruption 8 5.00 Toxicity 2 5.00 Arrhythmia Under Development 2 5.00 Ataxia 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Mutant DMPK-mediated effect on subcellular localization, and defective phosphorylation of cytoplasmic CUG-BP1, have additionally been linked to defective translation of p21 and MEF2A in DM1, possibly explaining delayed differentiation of DM1 muscle cells.

Localization (translation) of MEF2A in muscle cells

1) Confidence 0.40 Published 2008 Journal Current Genomics Section Abstract Doc Link PMC2694559 Disease Relevance 0.40 Pain Relevance 0

General Comments

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