INT272877

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Context Info
Confidence 0.75
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 1.68
Pain Relevance 0.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ccr2) signal transduction (Ccr2) plasma membrane (Ccr2)
signal transducer activity (Ccr2)
Anatomy Link Frequency
monocytes 1
Ccr2 (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 9 88.12 High High
Pain 3 86.76 High High
Peripheral nervous system 3 84.72 Quite High
Inflammation 166 82.64 Quite High
chemokine 41 50.00 Quite Low
cytokine 25 38.00 Quite Low
antagonist 22 18.60 Low Low
metalloproteinase 19 5.00 Very Low Very Low Very Low
Bioavailability 11 5.00 Very Low Very Low Very Low
Multiple sclerosis 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Multiple Sclerosis 135 93.84 High High
Stress 23 87.08 High High
Pain 3 86.76 High High
Targeted Disruption 40 85.20 High High
INFLAMMATION 175 82.64 Quite High
Pulmonary Disease 144 80.72 Quite High
Peritonitis 21 70.48 Quite High
Disease 55 61.48 Quite High
Injury 14 60.80 Quite High
Nicotine Addiction 49 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In Ccr2RFP/RFPCx3cr1GFP/+ mice, however, Ly6Chi cells were drastically reduced, both in number and as a percentage of CD45hi infiltrating cells, demonstrating the importance of CCR2 for recruitment of this subset into the CNS.
Localization (importance) of CCR2
1) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965160 Disease Relevance 0.42 Pain Relevance 0.08
Figure 6A shows a periventricular lesion visualized for CCR2 (RFP, red), CX3CR1 (GFP, green), and 7/4 (Cy5, blue).
Localization (visualized) of CCR2
2) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965160 Disease Relevance 0.25 Pain Relevance 0.17
Additional signals might initiate CCR2 translation in these monocytes and thus provide the potential to rapidly upregulate CCR2 expression.
Localization (translation) of CCR2 in monocytes
3) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965160 Disease Relevance 0.41 Pain Relevance 0.10
These effects were inhibitable by antioxidants including N-acetylcysteine, ascorbic acid, quercetin or overexpression of SOD1, deletion of CCR2, or by inhibition of MAPK p42/44 or p38 (Nishi et al 2005; Guest et al 2006; Hayasaki et al 2006; Huang et al 2006; Loke et al 2006).
Localization (deletion) of CCR2
4) Confidence 0.28 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695202 Disease Relevance 0.60 Pain Relevance 0.11

General Comments

This test has worked.

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