INT273063

Context Info Confidence 0.01 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.72 Pain Relevance 0.11

aging (Fas, Bcl2) nucleus (Fas, Bcl2) cytoplasm (Fas, Bcl2) mitochondrion (Bcl2) growth (Bcl2) cell death (Bcl2)

Fas (Rattus norvegicus) Bcl2 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Kinase C 1 100.00 ischemia 1 58.68 Potency 1 55.20 Nerve growth factor 2 44.96 Dopamine 18 5.00 monoamine 6 5.00 Serotonin 5 5.00 sSRI 4 5.00 sNRI 2 5.00 antidepressant 2 5.00

Disease Link Frequency Relevance Heat Apoptosis 5 100.00 Pheochromocytoma 4 80.56 Death 7 77.68 Neuroblastoma 2 61.92 Cv Unclassified Under Development 1 58.68 Brain Injury 1 57.88 Disease 42 50.00 Parkinson's Disease 4 40.72 Drug Induced Neurotoxicity 2 36.40 Stroke 2 23.12

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

This normally causes inhibition of the ubiquitin-proteosome complex and release of proapoptotic factors.36 Direct binding of the propargylamine moiety, however, prevents downstream activation of proapoptotic factors,37–40 partially via activation of anti-apoptotic factors including Bcl-2 and protein kinase C, and also by downregulation of proapoptotic catalysts including FAS and Bax protein families.36

Negative_regulation (downregulation) of FAS Negative_regulation (prevents) of Positive_regulation (activation) of Bcl-2 associated with kinase c and apoptosis

1) Confidence 0.01 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2695242 Disease Relevance 0.72 Pain Relevance 0.11

General Comments

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