INT273333

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Context Info
Confidence 0.18
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.30
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Twist1) nucleus (Twist1) DNA binding (Twist1)
transcription factor binding (Twist1)
Anatomy Link Frequency
neutrophils 2
Twist1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory marker 4 86.12 High High
Potency 5 83.88 Quite High
Inflammation 31 68.52 Quite High
Inflammatory response 4 38.88 Quite Low
chemokine 4 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
Inflammatory mediators 1 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 33 85.80 High High
Pulmonary Disease 19 75.92 Quite High
Asthma 4 69.12 Quite High
Pneumonia 7 50.00 Quite Low
Targeted Disruption 5 27.12 Quite Low
Vomiting 3 5.00 Very Low Very Low Very Low
Emphysema 3 5.00 Very Low Very Low Very Low
Disease 2 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 2 5.00 Very Low Very Low Very Low
Exsanguination 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, we observed that the dose required to achieve significant inhibition of the three PDE targets at the mRNA level (0.2 mg/kg/day) was the same as the dose required to block the recruitment of neutrophils, KC and pro-MMP-9.
Negative_regulation (inhibition) of Regulation (targets) of PDE in neutrophils
1) Confidence 0.18 Published 2009 Journal Respir Res Section Body Doc Link PMC2696437 Disease Relevance 0.30 Pain Relevance 0.12

General Comments

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