INT273505

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Context Info
Confidence 0.14
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.32
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

GTPase activity (GBP4) cytoplasm (GBP4)
Anatomy Link Frequency
Monocytes 1
GBP4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 2 39.04 Quite Low
Tetrahydrobiopterin 2 23.44 Low Low
withdrawal 58 5.00 Very Low Very Low Very Low
corticosteroid 12 5.00 Very Low Very Low Very Low
abdominal pain 4 5.00 Very Low Very Low Very Low
Bile 2 5.00 Very Low Very Low Very Low
tolerance 2 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Organ Transplantation 4 75.40 Quite High
Bacterial Respiratory Disease 2 68.24 Quite High
Adhesions 4 60.88 Quite High
Toxicity 6 49.04 Quite Low
INFLAMMATION 2 39.04 Quite Low
Graft Vs Host Disease 4 29.04 Quite Low
Renal Failure 48 5.00 Very Low Very Low Very Low
Death 14 5.00 Very Low Very Low Very Low
Infection 12 5.00 Very Low Very Low Very Low
Cytomegalovirus Infection 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Monocytes are also affected by therapeutic doses of MPA, as it significantly decreases guanosine triphosphate (GTP) pools in human peripheral blood monocytes but not in neutrophils.8 By preferential depletion of guanosine and deoxyguanosine nucleotides in T and B lymphocytes, MPA suppresses both cell mediated immune responses and antibody formation, major factors in both acute and chronic allograft rejection.
Negative_regulation (doses) of MPA in Monocytes
1) Confidence 0.14 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2697521 Disease Relevance 0.12 Pain Relevance 0
By inhibiting IMPDH, MPA prevents formation of guanosine monophosphate (GMP).
Negative_regulation (inhibiting) of MPA
2) Confidence 0.06 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2697521 Disease Relevance 0.20 Pain Relevance 0

General Comments

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