INT273508

Context Info Confidence 0.21 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.17 Pain Relevance 0

isomerase activity (Top2a) nucleoplasm (Top2a) chromosome segregation (Top2a) enzyme binding (Top2a) DNA binding (Top2a) protein complex (Top2a)

Top2a (Mus musculus)

Pain Link Frequency Relevance Heat Pain 4 28.20 methotrexate 1 5.00 Inflammation 1 5.00 Potency 1 5.00

Disease Link Frequency Relevance Heat Stress 2 98.60 Injury 12 50.00 Infection 2 29.68 Pain 3 28.20 Necrosis 8 16.88 Cancer 5 5.00 Ulcers 2 5.00 Vomiting 2 5.00 Disorders Of Creatine Metabolism 1 5.00 Breast Cancer 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Reduction of oxidative stress due to complexes of metal ions and anthracyclines by chelating metal ionsBlockade of topoisomerase II poisons by catalytic inhibition of topoisomerase II

Negative_regulation (ionsBlockade) of Gene_expression (poisons) of topoisomerase II associated with stress

1) Confidence 0.21 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2697522 Disease Relevance 0.17 Pain Relevance 0

General Comments

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