INT27356

Context Info Confidence 0.78 First Reported 1983 Last Reported 2008 Negated 0 Speculated 1 Reported most in Abstract Documents 8 Total Number 9 Disease Relevance 3.44 Pain Relevance 1.39

nucleoplasm (NEUROD1) nucleus (NEUROD1) transcription factor binding (NEUROD1) cytoplasm (NEUROD1)

Anatomy Link Frequency endothelial cells 1 odontoblasts 1 proximal 1 NEUROD1 (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammatory marker 2 99.42 sodium channel 4 98.12 Angina 2 95.92 Pain 5 94.60 aspirin 4 89.88 Action potential 1 84.60 tetrodotoxin 2 79.44 abdominal pain 1 75.84 anesthesia 11 75.00 Analgesic 3 75.00

Disease Link Frequency Relevance Heat Toxicity 1 99.58 INFLAMMATION 3 99.26 Renal Disease 7 97.98 Disorders Of Creatine Metabolism 6 96.76 Syndrome 1 96.74 Increased Venous Pressure Under Development 2 96.56 Cv General 3 Under Development 2 95.92 Myocardial Infarction 3 95.12 Pain 4 94.60 Low Cardiac Output 3 94.08

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Anatomy

Negation

Speculation

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Disease term

Urinary N-acetyl-beta-D-glucosaminidase (U-NAG) and fractional excretion of beta 2-microglobulin (FE beta 2M) in addition to conventional renal parameters such as creatinine clearance (Ccr) and free water clearance (CH2O) were measured before and during IABP.

Localization (excretion) of beta 2 associated with disorders of creatine metabolism

1) Confidence 0.78 Published 1989 Journal Nippon Kyobu Geka Gakkai Zasshi Section Abstract Doc Link 2600464 Disease Relevance 0.91 Pain Relevance 0.19

Localization of the sites of iodination of human beta 2-microglobulin: quaternary structure implications for histocompatibility antigens.

Localization (Localization) of beta 2

2) Confidence 0.78 Published 1983 Journal Biochemistry Section Title Doc Link 6188486 Disease Relevance 0.09 Pain Relevance 0.09

The patients who were routinely found to have no signs of nephropathy showed no dysfunction of renal glomeruli and distal or proximal tubule as determined by the urinary excretion of albumins, Tamm-Horsfall protein and beta-2-microglobulins prior to the operation.

Spec (determined) Localization (excretion) of beta-2 in proximal associated with renal disease

3) Confidence 0.78 Published 2003 Journal Wiad. Lek. Section Abstract Doc Link 15049201 Disease Relevance 0.25 Pain Relevance 0.07

Different anaesthesia techniques had no effect on the urinary excretion of beta-2-microglobulins.

Localization (excretion) of beta-2

4) Confidence 0.78 Published 2003 Journal Wiad. Lek. Section Abstract Doc Link 15049201 Disease Relevance 0.24 Pain Relevance 0.07

Ankyrin(G) and beta2 co-localize, suggesting a link for signal transduction between axons and odontoblasts.

Localization (localize) of beta2 in odontoblasts

5) Confidence 0.78 Published 2006 Journal J. Biol. Chem. Section Abstract Doc Link 16831873 Disease Relevance 0.15 Pain Relevance 0.52

This dose of Cd produced borderline tubular toxicity, as measured by the excretion of IV-injected human beta 2-microglobulin.

Localization (excretion) of beta 2 associated with toxicity

6) Confidence 0.73 Published 1984 Journal Arch. Toxicol. Section Abstract Doc Link 6517702 Disease Relevance 0.26 Pain Relevance 0.22

NAG excretion started to increase after inhalation of either sevoflurane or isoflurane. alpha 1-M and beta 2-M excretion increased markedly postoperatively.

Localization (excretion) of beta 2

7) Confidence 0.73 Published 1994 Journal J Clin Anesth Section Body Doc Link 7527229 Disease Relevance 0.06 Pain Relevance 0

The patient was referred to our hospital, and suspected to have vasculitis syndrome since the abnormal laboratory findings included persistently increased levels of FDP-E/fibrin monomer as well as inflammatory markers, and the extraordinary high excretion of beta 2-microglobulin, which indicated abrupt and massive expression of HLA class I molecule on endothelial cells due to interferon-gammanemia.

Localization (excretion) of beta 2 in endothelial cells associated with syndrome, inflammatory marker and increased venous pressure under development

8) Confidence 0.73 Published 2008 Journal Nihon Rinsho Meneki Gakkai Kaishi Section Abstract Doc Link 18974626 Disease Relevance 1.41 Pain Relevance 0.15

In situ hybridization histochemistry was used to localize mRNAs of the genes encoding monkey-specific alpha 1, alpha 2, alpha 4, alpha 5, beta 1, beta 2, and gamma 2 subunits.

Localization (localize) of beta 2

9) Confidence 0.68 Published 1995 Journal J. Comp. Neurol. Section Abstract Doc Link 7721992 Disease Relevance 0.07 Pain Relevance 0.06

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