INT273715

Context Info Confidence 0.07 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 1.51 Pain Relevance 0.16

extracellular space (Icam1) cell adhesion (Icam1) plasma membrane (Icam1)

Anatomy Link Frequency T cell 4 Icam1 (Mus musculus) Trav6-3 (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 8 85.12 antagonist 14 5.00 antidepressant 12 5.00 fluoxetine 4 5.00 Serotonin 4 5.00 sSRI 2 5.00 Desipramine 2 5.00 Kinase C 2 5.00 imagery 2 5.00 Potency 2 5.00

Disease Link Frequency Relevance Heat Adhesions 4 100.00 Disease 2 89.44 Autoimmune Disease 6 86.08 INFLAMMATION 8 85.12 Immune System Diseases 2 83.96 Targeted Disruption 12 82.72 Infection 2 72.20 Syndrome 4 5.00 Hypersensitivity 2 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

When the ‘inside-out’ signal is induced by interaction of specific receptors with their ligands, e.g., interaction of T cell receptor (TCR) with cognate peptide/MHC complexes (pMHCs), both affinity and avidity of LFA-1 for its ligand, intercellular adhesion molecule-1 (ICAM-1), are enhanced by its conformational change and spatial rearrangement.

Positive_regulation (enhanced) of intercellular adhesion molecule-1 Binding (interaction) of TCR in T cell associated with adhesions

1) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2698288 Disease Relevance 0.75 Pain Relevance 0.08

When the ‘inside-out’ signal is induced by interaction of specific receptors with their ligands, e.g., interaction of T cell receptor (TCR) with cognate peptide/MHC complexes (pMHCs), both affinity and avidity of LFA-1 for its ligand, intercellular adhesion molecule-1 (ICAM-1), are enhanced by its conformational change and spatial rearrangement.

Positive_regulation (enhanced) of ICAM-1 Binding (interaction) of TCR in T cell associated with adhesions

2) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2698288 Disease Relevance 0.75 Pain Relevance 0.08

General Comments

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