INT273719

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Context Info
Confidence 0.07
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.47
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Itgb2)
Anatomy Link Frequency
T cell 2
Itgb2 (Mus musculus)
Trav6-3 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 8 54.12 Quite High
antagonist 14 5.00 Very Low Very Low Very Low
antidepressant 12 5.00 Very Low Very Low Very Low
fluoxetine 4 5.00 Very Low Very Low Very Low
Serotonin 4 5.00 Very Low Very Low Very Low
sSRI 2 5.00 Very Low Very Low Very Low
Desipramine 2 5.00 Very Low Very Low Very Low
Kinase C 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Potency 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 12 85.72 High High
Adhesions 4 75.16 Quite High
Disease 2 58.44 Quite High
Autoimmune Disease 6 55.08 Quite High
INFLAMMATION 8 54.12 Quite High
Immune System Diseases 2 52.96 Quite High
Infection 2 41.20 Quite Low
Syndrome 4 5.00 Very Low Very Low Very Low
Hypersensitivity 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The eMV-absorption by 2C T cells was found to be mediated by specific dual receptor/ligand interactions of 2C TCR with a cognate pMHC (Ld/QL9 or Ld/p2Ca) plus LFA-1 with ICAM-1.
LFA-1 Binding (interactions) of 2C TCR in T cells
1) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2698288 Disease Relevance 0.47 Pain Relevance 0.03
Secondly, using 2C T cells deficient in CD28 or LFA-1 expression and mAbs blocking interactions of those receptors with their ligands, it is feasible to probe the contributing roles of TCR/pMHC, CD28/B7-1 and LFA-1/ICAM-1 interactions in the pMV-absorption.

2C T cell absorption of LdB7-1ICAM-1 Dros pMVs

LFA-1 Binding (interactions) of TCR in T cell
2) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2698288 Disease Relevance 0 Pain Relevance 0

General Comments

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