INT273944

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Context Info
Confidence 0.26
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.62
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Creb1, Crem) DNA binding (Creb1, Crem) mitochondrion (Creb1)
transcription factor binding (Creb1)
Creb1 (Mus musculus)
Crem (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 3 99.76 Very High Very High Very High
Eae 7 5.00 Very Low Very Low Very Low
Dopamine 5 5.00 Very Low Very Low Very Low
Nucleus accumbens 5 5.00 Very Low Very Low Very Low
Hippocampus 5 5.00 Very Low Very Low Very Low
antidepressant 4 5.00 Very Low Very Low Very Low
addiction 4 5.00 Very Low Very Low Very Low
depression 3 5.00 Very Low Very Low Very Low
amygdala 2 5.00 Very Low Very Low Very Low
orphanin 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 24 92.08 High High
Anxiety Disorder 12 90.48 High High
Stress 11 5.00 Very Low Very Low Very Low
Convulsion 10 5.00 Very Low Very Low Very Low
Apoptosis 8 5.00 Very Low Very Low Very Low
Epilepsy 6 5.00 Very Low Very Low Very Low
Drug Dependence 4 5.00 Very Low Very Low Very Low
Depression 3 5.00 Very Low Very Low Very Low
Shock 3 5.00 Very Low Very Low Very Low
Status Epilepticus 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The disruption of CREB gene results not only in the impairment of long-term memory but also leads to the significant upregulation of several CREM isoforms, ICER in particular [86].
Negative_regulation (disruption) of CREB gene Positive_regulation (leads) of Positive_regulation (upregulation) of CREM
1) Confidence 0.26 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2699388 Disease Relevance 0.62 Pain Relevance 0.05

General Comments

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