INT273944

Context Info Confidence 0.26 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.62 Pain Relevance 0.05

nucleus (Creb1, Crem) DNA binding (Creb1, Crem) mitochondrion (Creb1) transcription factor binding (Creb1)

Creb1 (Mus musculus) Crem (Mus musculus)

Pain Link Frequency Relevance Heat antagonist 3 99.76 Eae 7 5.00 Dopamine 5 5.00 Nucleus accumbens 5 5.00 Hippocampus 5 5.00 antidepressant 4 5.00 addiction 4 5.00 depression 3 5.00 amygdala 2 5.00 orphanin 2 5.00

Disease Link Frequency Relevance Heat Targeted Disruption 24 92.08 Anxiety Disorder 12 90.48 Stress 11 5.00 Convulsion 10 5.00 Apoptosis 8 5.00 Epilepsy 6 5.00 Drug Dependence 4 5.00 Depression 3 5.00 Shock 3 5.00 Status Epilepticus 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The disruption of CREB gene results not only in the impairment of long-term memory but also leads to the significant upregulation of several CREM isoforms, ICER in particular [86].

Negative_regulation (disruption) of CREB gene Positive_regulation (leads) of Positive_regulation (upregulation) of CREM

1) Confidence 0.26 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2699388 Disease Relevance 0.62 Pain Relevance 0.05

General Comments

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