INT274054

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Context Info
Confidence 0.12
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (CYP1A1) mitochondrion (CYP1A1) small molecule metabolic process (CYP1A1)
oxidoreductase activity (CYP1A1) endoplasmic reticulum (CYP1A1) enzyme binding (CYP1A1)
Anatomy Link Frequency
MT2 1
CYP1A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 20 80.20 Quite High
Bioavailability 3 52.08 Quite High
GABAergic 8 5.00 Very Low Very Low Very Low
Serotonin 4 5.00 Very Low Very Low Very Low
withdrawal 4 5.00 Very Low Very Low Very Low
depression 3 5.00 Very Low Very Low Very Low
addiction 3 5.00 Very Low Very Low Very Low
tolerance 3 5.00 Very Low Very Low Very Low
Thalamus 3 5.00 Very Low Very Low Very Low
antidepressant 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sleep Initiation And Maintenance Disorders 24 50.00 Quite Low
Disease 11 5.00 Very Low Very Low Very Low
Circadian Rhythm Sleep Disorders 6 5.00 Very Low Very Low Very Low
Sleep Disorders 5 5.00 Very Low Very Low Very Low
Depression 5 5.00 Very Low Very Low Very Low
Autoimmune Disease 4 5.00 Very Low Very Low Very Low
Hyperplasia 2 5.00 Very Low Very Low Very Low
Neurological Disease 2 5.00 Very Low Very Low Very Low
Pulmonary Disease 2 5.00 Very Low Very Low Very Low
Functional Bowel Disorder 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Melatonin itself has different affinities to human MT1 and MT2 receptors (Ki = 80.7 and 383 pM, respectively).21,47 Its physiological half-life in the circulation is, as mentioned, usually less than half an hour, mainly because of rapid hepatic 6-hydroxylation by cytochrome P450 monooxygenase subforms, in particular, CYP1A2, but also CYP1A1 and CYP1B1.48,49 6-Hydroxymelatonin is conjugated and excreted.
Localization (excreted) of CYP1A1 in MT2
1) Confidence 0.12 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2699659 Disease Relevance 0 Pain Relevance 0.07

General Comments

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