INT27408

Context Info Confidence 0.80 First Reported 1984 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 9 Total Number 9 Disease Relevance 2.18 Pain Relevance 5.88

small molecule metabolic process (POMC) cell-cell signaling (POMC) cytoplasm (POMC) extracellular space (POMC) generation of precursor metabolites and energy (POMC) signal transduction (POMC)

Anatomy Link Frequency putamen 1 digestive tract 1 body 1 POMC (Homo sapiens)

Pain Link Frequency Relevance Heat Enkephalin 21 100.00 chemokine 7 100.00 Endogenous opioid 4 100.00 Catecholamine 2 99.60 noradrenaline 1 99.56 Dynorphin 9 99.22 headache 72 98.12 halothane 10 97.00 Opioid 10 96.08 midbrain 1 94.96

Disease Link Frequency Relevance Heat Schizophrenia 3 99.40 Skin Cancer 2 98.16 Post-dural Puncture Headache 51 98.12 Increased Venous Pressure Under Development 2 96.36 Headache 20 92.64 Pain 17 91.44 Heart Rate Under Development 1 86.88 Disease 1 82.64 Diabetes Mellitus 1 82.00 Occupational Lung Diseases 1 72.68

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Proenkephalin A processing in the upper digestive tract: isolation and characterisation of phosphorylated N-terminally extended Met-enkephalin Arg6Phe7 variants.

Phosphorylation (phosphorylated) of Met-enkephalin in digestive tract associated with enkephalin

1) Confidence 0.80 Published 1988 Journal J. Neurochem. Section Title Doc Link 3418349 Disease Relevance 0 Pain Relevance 0.29

Melanoma cells homozygous for either the Arg151Cys variant or consensus sequence both elicited CREB phosphorylation in response to alpha-MSH in the presence of IBMX.

Phosphorylation (phosphorylation) of alpha-MSH associated with skin cancer

2) Confidence 0.72 Published 2005 Journal Peptides Section Abstract Doc Link 15992961 Disease Relevance 0.17 Pain Relevance 0.32

Furthermore, a significant increase in the formation of the putative neuroleptic-like peptide fragment des-enkephalin-gamma-endorphin in postmortem schizophrenic putamen versus controls was shown.

Phosphorylation (formation) of des-enkephalin-gamma-endorphin in putamen associated with enkephalin and schizophrenia

3) Confidence 0.71 Published 1984 Journal Peptides Section Abstract Doc Link 6085162 Disease Relevance 0.35 Pain Relevance 0.14

The concentrations of met-enkephalin, dynorphin and catecholamines did not change and those of beta-endorphin, adrenocorticotrophin, arginine vasopressin and cortisol increased during halothane anaesthesia.

Phosphorylation (those) of beta-endorphin associated with dynorphin, catecholamine, halothane and enkephalin

4) Confidence 0.69 Published 1995 Journal Res. Vet. Sci. Section Abstract Doc Link 7709057 Disease Relevance 0.09 Pain Relevance 0.86

Apart from activating the body’s system of temperature regulation, there is also a hormonal response, which increases body metabolism and the concentrations of adrenaline, noradrenaline, adrenocorticotropic hormone (ACTH), cortisone, pro-opiomelanocortin (POMC), and ?

Phosphorylation (hormone) of ACTH in body associated with noradrenaline

5) Confidence 0.52 Published 2008 Journal Arch Immunol Ther Exp (Warsz) Section Body Doc Link PMC2734249 Disease Relevance 0.13 Pain Relevance 0.29

The several proposed mechanisms of action, involving serotoninergic, catecholaminergic, Ca2+ fluxes, protein phosphorylation, beta-endorphin production, cyclooxygenase inhibition and histamine interference are also reviewed.

Phosphorylation (phosphorylation) of beta-endorphin

6) Confidence 0.34 Published 1994 Journal Agents Actions Section Abstract Doc Link 7942319 Disease Relevance 0.17 Pain Relevance 0.64

A novel modified form of Met-enkephalin was detected.

Phosphorylation (form) of Met-enkephalin associated with enkephalin

7) Confidence 0.18 Published 1989 Journal Peptides Section Abstract Doc Link 2608557 Disease Relevance 0 Pain Relevance 1.46

Previous studies show that Met-enkephalin, an endogenous opioid, down-regulates chemotaxis of selected chemokine receptors via phosphorylation.

Phosphorylation (phosphorylation) of Met-enkephalin associated with chemokine, endogenous opioid and enkephalin

8) Confidence 0.10 Published 2003 Journal J. Biol. Chem. Section Abstract Doc Link 12551901 Disease Relevance 0 Pain Relevance 0.65

Cosyntropin, a synthetic form of adrenocorticotropic hormone, has been used in the treatment of refractory PDPH.

Phosphorylation (form) of adrenocorticotropic hormone associated with headache

9) Confidence 0.02 Published 2010 Journal Anesthesiology Research and Practice Section Body Doc Link PMC2931374 Disease Relevance 1.27 Pain Relevance 1.23

General Comments

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