INT274096

Context Info Confidence 0.22 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.78 Pain Relevance 0

cell-cell signaling (EDN1, EDN1) cytoplasm (EDN1, EDN1) extracellular space (EDN1, EDN1) extracellular region (EDN1, EDN1) aging (EDNRA) signal transducer activity (EDNRA)

EDN1 (Homo sapiens) EDNRA (Homo sapiens) EDN1 (Homo sapiens)

Pain Link Frequency Relevance Heat cva 7 17.68 ischemia 18 5.00 Calcium channel 9 5.00 Migraine 5 5.00 Inflammation 4 5.00 antagonist 3 5.00 Multiple sclerosis 2 5.00 rheumatoid arthritis 2 5.00 Serotonin 2 5.00 Catecholamine 2 5.00

Disease Link Frequency Relevance Heat Increased Venous Pressure Under Development 95 100.00 Low Tension Glaucoma 17 76.48 Glaucoma 101 74.64 Eye Disease 1 34.00 Cv General 3 Under Development 5 17.68 Renal Failure 1 13.76 Myocardial Infarction 3 13.16 Cv Unclassified Under Development 24 11.64 Disease 27 5.00 Ocular Hypertension 23 5.00

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Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

This suggests that low ET-1 doses have a greater affinity for ETB receptors to cause vasodilation, but increased levels of ET-1 leads to vasoconstriction by binding to ETA receptors.

ET-1 Binding (binding) of ETA Positive_regulation (leads) of Positive_regulation (increased) of ET-1 associated with increased venous pressure under development

1) Confidence 0.22 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2699797 Disease Relevance 0.78 Pain Relevance 0

General Comments

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