INT274621

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Context Info
Confidence 0.80
First Reported 2009
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 15
Disease Relevance 1.48
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PSTPIP1) signal transduction (PSTPIP1) oxidoreductase activity (PSTPIP1)
cell adhesion (PSTPIP1) cytoskeleton (PSTPIP1) cytoplasm (PSTPIP1)
Anatomy Link Frequency
filaments 5
SH3 2
PSTPIP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 135 83.44 Quite High
Arthritis 30 62.04 Quite High
Pain 30 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Syndrome 135 85.20 High High
INFLAMMATION 135 83.44 Quite High
Disease 150 82.40 Quite High
Fever 165 73.36 Quite High
Acne 30 63.32 Quite High
Pyoderma Gangrenosum 30 62.92 Quite High
Arthritis 30 62.04 Quite High
Osteomyelitis 60 5.00 Very Low Very Low Very Low
Pain 30 5.00 Very Low Very Low Very Low
Adhesions 15 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this case, pyrin is localized in 100% of specks, but PSTPIP1 is never localized in specks (Figure 9Q–S).
Localization (localized) of PSTPIP1
1) Confidence 0.80 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2702820 Disease Relevance 0.07 Pain Relevance 0
Taken together, our data support the notion that the increased pyrin binding affinity of PAPA mutations alter the cellular localization of PSTPIP1, bringing it to a compartment in which it might act to intensify inflammasome signaling.
Localization (localization) of PSTPIP1
2) Confidence 0.80 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2702820 Disease Relevance 0.19 Pain Relevance 0.03
Finally, we demonstrate that pyrin can recruit PSTPIP1 into aggregations (specks) of ASC, another pyrin binding protein.
Localization (recruit) of PSTPIP1
3) Confidence 0.75 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2702820 Disease Relevance 0.67 Pain Relevance 0.03
This region might also be a PEST phosphatase interaction surface, since pyrin and PEST phosphatase are thought to bind to the same region of PSTPIP1 and the PAPA mutations increase affinity for pyrin while decreasing affinity for PEST phophatases [5].
Localization (phosphatase) of PEST
4) Confidence 0.75 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2702820 Disease Relevance 0 Pain Relevance 0
First, our studies show clearly that the SH3 domain of PSTPIP1 is not required for pyrin binding nor is it necessary for pyrin-mediated reticularization of PSTPIP1 filaments.
Localization (reticularization) of PSTPIP1 in SH3
5) Confidence 0.75 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2702820 Disease Relevance 0 Pain Relevance 0
It was not possible to simultaneously image both pyrin and PSTPIP1 in human cells since both primary antibodies were generated in rabbits.


Localization (image) of PSTPIP1
6) Confidence 0.75 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2702820 Disease Relevance 0 Pain Relevance 0
Additionally, a mutation in the CC region of PSTPIP1, W232A, abolished PSTPIP1 binding both to pyrin [5] and to the PEST phosphatase, PTP-HSCF [8].
Localization (region) of PSTPIP1
7) Confidence 0.75 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2702820 Disease Relevance 0 Pain Relevance 0
We were not able to discern an effect of either pyrin mutations or PSTPIP1 mutations on the property of PSTPIP1 filament reticularization.
Localization (reticularization) of PSTPIP1 in filament
8) Confidence 0.75 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2702820 Disease Relevance 0.17 Pain Relevance 0.03
Additionally, a mutation in the CC region of PSTPIP1, W232A, abolished PSTPIP1 binding both to pyrin [5] and to the PEST phosphatase, PTP-HSCF [8].
Localization (phosphatase) of PEST
9) Confidence 0.75 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2702820 Disease Relevance 0 Pain Relevance 0
We therefore examined the effect of the W232A mutation and the requirement for the SH3 domain on pyrin's recruitment to and reticularization of PSTPIP1 filaments.
Localization (reticularization) of PSTPIP1 in SH3
10) Confidence 0.75 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2702820 Disease Relevance 0 Pain Relevance 0
In contrast, the W232A mutation in PSTPIP1 abolished pyrin binding; consequently, PSTPIP1 filaments were primarily straight, not extensively branched (Figure 4I–K), confirming that the reticularization of PSTPIP1 filaments is a direct consequence of pyrin binding.
Localization (reticularization) of PSTPIP1 in filaments
11) Confidence 0.75 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2702820 Disease Relevance 0 Pain Relevance 0
In addition, we explore the connection between PSTPIP1 filaments and the cellular cytoskeleton and demonstrate that pyrin binding affects PSTPIP1 filament distribution.
Localization (distribution) of PSTPIP1 in filaments
12) Confidence 0.75 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2702820 Disease Relevance 0.17 Pain Relevance 0.04
Pyrin exons 2–4 produced a protein capable of aligning with PSTPIP1 filaments, but the PSTPIP1 filament network was not reticularized (Figure 5E–F).
Neg (not) Localization (reticularized) of PSTPIP1 in filament
13) Confidence 0.75 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2702820 Disease Relevance 0.06 Pain Relevance 0
PSTPIP1 filaments co-localized with DiIC16 staining (Figure 7A–C) as previously described for the related protein, FBP17[21].
Localization (localized) of PSTPIP1 in filaments
14) Confidence 0.70 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2702820 Disease Relevance 0.07 Pain Relevance 0
In this case, pyrin is localized in 100% of specks, but PSTPIP1 is never localized in specks (Figure 9Q–S).
Localization (localized) of PSTPIP1
15) Confidence 0.70 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2702820 Disease Relevance 0.08 Pain Relevance 0

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