INT274873

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Context Info
Confidence 0.28
First Reported 2009
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 1.04
Pain Relevance 1.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
brain 1
microglia 1
Cbr2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 40 100.00 Very High Very High Very High
agonist 40 100.00 Very High Very High Very High
Cannabinoid receptor 24 99.36 Very High Very High Very High
Cannabinoid 24 98.88 Very High Very High Very High
Inflammation 84 96.00 Very High Very High Very High
Spinal cord 8 88.80 High High
Peripheral nerve injury 24 87.84 High High
imagery 4 86.12 High High
Pain 12 85.08 High High
chemokine 4 79.52 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 92 96.00 Very High Very High Very High
Hypersensitivity 20 95.32 Very High Very High Very High
Frailty 8 89.08 High High
Nervous System Injury 36 86.96 High High
Pain 20 85.08 High High
Cancer 12 53.12 Quite High
Necrosis 12 52.64 Quite High
Drug Induced Neurotoxicity 4 43.68 Quite Low
Diabetes Mellitus 4 20.00 Low Low
Neuropathic Pain 28 6.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CBR2 are expressed in glia in normal human and rat brain [8,9] and their glial expression increases especially during inflammation [10,11].
Gene_expression (expressed) of CBR2 in brain associated with inflammation
1) Confidence 0.28 Published 2009 Journal Mol Pain Section Body Doc Link PMC2704199 Disease Relevance 1.04 Pain Relevance 0.86
To test the specificity of the CBR2 agonist, we challenged its effects with specific CBR1 (AM281) and CBR2 (AM630) antagonists by using the following groups: LPS + JWH015 (1 ?
Gene_expression (agonist) of CBR2 associated with antagonist and agonist
2) Confidence 0.24 Published 2009 Journal Mol Pain Section Body Doc Link PMC2704199 Disease Relevance 0 Pain Relevance 0.14
M group was blocked by the CBR2 selective antagonist AM630, but not by the CBR1 selective antagonist AM281 (45 ± 3 vs. 73 ± 4 or 54 ± 3 cells in LPS+JWH015+AM630 or AM281 respectively; Figure 6B).
Neg (not) Gene_expression (selective) of CBR2 associated with antagonist
3) Confidence 0.24 Published 2009 Journal Mol Pain Section Body Doc Link PMC2704199 Disease Relevance 0 Pain Relevance 0.21
The selective CBR2 antagonist, AM630, but not the CBR1 antagonist, AM281, significantly blocked the JWH015-induced MKP-3 in LPS stimulated microglia (1.12 ± 0.02 vs. 1.05 ± 0.02 of LPS alone group, LPS + JWH015 1 ?
Gene_expression (antagonist) of CBR2 in microglia associated with antagonist
4) Confidence 0.24 Published 2009 Journal Mol Pain Section Body Doc Link PMC2704199 Disease Relevance 0 Pain Relevance 0.20

General Comments

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