INT274880

Context Info Confidence 0.04 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 3 Disease Relevance 0.89 Pain Relevance 0.52

cell differentiation (Dusp6) cytosol (Dusp6) cytoplasm (Dusp6)

Dusp6 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Inflammation 63 100.00 agonist 30 98.24 Cannabinoid receptor 18 75.00 cINOD 3 48.40 dexamethasone 3 45.76 addiction 6 9.44 antagonist 30 5.00 Peripheral nerve injury 18 5.00 Cannabinoid 18 5.00 Central nervous system 12 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 69 100.00 Alzheimer's Dementia 3 90.80 Necrosis 9 77.84 Cancer 9 77.48 Nervous System Injury 27 5.00 Neuropathic Pain 21 5.00 Pain 15 5.00 Hypersensitivity 15 5.00 Frailty 6 5.00 Neurological Disease 3 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

These data suggest that the reduction of pro-inflammatory factors and microglial migration via MKP-3 induction is part of the mechanism of action of CBR2 agonists.

Negative_regulation (reduction) of Positive_regulation (induction) of MKP-3 associated with inflammation and agonist

1) Confidence 0.04 Published 2009 Journal Mol Pain Section Abstract Doc Link PMC2704199 Disease Relevance 0.39 Pain Relevance 0.26

Triptolide, which blocked both MKP-1 and MKP-3 induction by JWH015, increased p-ERK in parallel.

Negative_regulation (blocked) of Positive_regulation (induction) of MKP-3

2) Confidence 0.04 Published 2009 Journal Mol Pain Section Body Doc Link PMC2704199 Disease Relevance 0.50 Pain Relevance 0.25

M), which completely inhibited the induction of both MKP-1 and MKP-3 by JWH015, induced a significant increase in p-ERK1 (1.14 ± 0.02 of LPS + JWH015 control group, p < 0.05; Figures 4A and 4B) and p-ERK2 (1.12 ± 0.02 of LPS + JWH015 control group, p < 0.05; Figures 4A and 4B).

Negative_regulation (inhibited) of Positive_regulation (induction) of MKP-3

3) Confidence 0.04 Published 2009 Journal Mol Pain Section Body Doc Link PMC2704199 Disease Relevance 0 Pain Relevance 0

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