INT274880

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Context Info
Confidence 0.04
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.89
Pain Relevance 0.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Dusp6) cytosol (Dusp6) cytoplasm (Dusp6)
Dusp6 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 63 100.00 Very High Very High Very High
agonist 30 98.24 Very High Very High Very High
Cannabinoid receptor 18 75.00 Quite High
cINOD 3 48.40 Quite Low
dexamethasone 3 45.76 Quite Low
addiction 6 9.44 Low Low
antagonist 30 5.00 Very Low Very Low Very Low
Peripheral nerve injury 18 5.00 Very Low Very Low Very Low
Cannabinoid 18 5.00 Very Low Very Low Very Low
Central nervous system 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 69 100.00 Very High Very High Very High
Alzheimer's Dementia 3 90.80 High High
Necrosis 9 77.84 Quite High
Cancer 9 77.48 Quite High
Nervous System Injury 27 5.00 Very Low Very Low Very Low
Neuropathic Pain 21 5.00 Very Low Very Low Very Low
Pain 15 5.00 Very Low Very Low Very Low
Hypersensitivity 15 5.00 Very Low Very Low Very Low
Frailty 6 5.00 Very Low Very Low Very Low
Neurological Disease 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data suggest that the reduction of pro-inflammatory factors and microglial migration via MKP-3 induction is part of the mechanism of action of CBR2 agonists.
Negative_regulation (reduction) of Positive_regulation (induction) of MKP-3 associated with inflammation and agonist
1) Confidence 0.04 Published 2009 Journal Mol Pain Section Abstract Doc Link PMC2704199 Disease Relevance 0.39 Pain Relevance 0.26
Triptolide, which blocked both MKP-1 and MKP-3 induction by JWH015, increased p-ERK in parallel.
Negative_regulation (blocked) of Positive_regulation (induction) of MKP-3
2) Confidence 0.04 Published 2009 Journal Mol Pain Section Body Doc Link PMC2704199 Disease Relevance 0.50 Pain Relevance 0.25
M), which completely inhibited the induction of both MKP-1 and MKP-3 by JWH015, induced a significant increase in p-ERK1 (1.14 ± 0.02 of LPS + JWH015 control group, p < 0.05; Figures 4A and 4B) and p-ERK2 (1.12 ± 0.02 of LPS + JWH015 control group, p < 0.05; Figures 4A and 4B).
Negative_regulation (inhibited) of Positive_regulation (induction) of MKP-3
3) Confidence 0.04 Published 2009 Journal Mol Pain Section Body Doc Link PMC2704199 Disease Relevance 0 Pain Relevance 0

General Comments

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