INT275123

Context Info Confidence 0.00 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 3 Disease Relevance 0.93 Pain Relevance 0

cytosol (SUGT1) mitosis (SUGT1) plasma membrane (HLA-E)

Anatomy Link Frequency T cell 2 HLA-E (Homo sapiens) SUGT1 (Homo sapiens)

Pain Link Frequency Relevance Heat fluoxetine 6 5.00 Bile 3 5.00 diclofenac 3 5.00 Inflammation 3 5.00 Inflammatory response 3 5.00

Disease Link Frequency Relevance Heat Blister 3 91.36 Adverse Drug Reaction 192 90.96 Staphylococcus Infection 81 84.56 Syndrome 78 75.44 Hypersensitivity 24 38.40 Deafness 21 5.00 Gallstones 18 5.00 Rhabdomyolysis 12 5.00 Acquired Immune Deficiency Syndrome Or Hiv Infection 6 5.00 INFLAMMATION 6 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Thirdly, von Greyerz et al [29] found that most T cell clones showed a “MHC-allele restricted drug-specific recognition” that was stimulated by the parent drug rather than its derivatives.

MHC Binding (recognition) of allele in T cell

1) Confidence 0.00 Published 2009 Journal PLoS Computational Biology Section Body Doc Link PMC2704868 Disease Relevance 0.32 Pain Relevance 0

Thirdly, von Greyerz et al [29] found that most T cell clones showed a “MHC-allele restricted drug-specific recognition” that was stimulated by the parent drug rather than its derivatives.

MHC Binding (recognition) of allele in T cell

2) Confidence 0.00 Published 2009 Journal PLoS Computational Biology Section Body Doc Link PMC2704868 Disease Relevance 0.32 Pain Relevance 0

In our model, a similar drug-MHC I recognition occurs when the drug binds to its specific “port” of a particular MHC allele at the variant region.

MHC Binding (binds) of allele

3) Confidence 0.00 Published 2009 Journal PLoS Computational Biology Section Body Doc Link PMC2704868 Disease Relevance 0.29 Pain Relevance 0

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