INT275364

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Context Info
Confidence 0.28
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.72
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Prkaca) nucleoplasm (Prkaca) mitochondrion (Prkaca)
Golgi apparatus (Prkaca) plasma membrane (Prkaca) nucleus (Prkaca)
Anatomy Link Frequency
brain 2
Prkaca (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 4 58.72 Quite High
Pyramidal cell 2 39.76 Quite Low
antagonist 3 30.16 Quite Low
Electroencephalography 13 5.00 Very Low Very Low Very Low
gABA 5 5.00 Very Low Very Low Very Low
Central nervous system 4 5.00 Very Low Very Low Very Low
GABAergic 3 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
Neurobehavioral 2 5.00 Very Low Very Low Very Low
Neurotransmitter 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Convulsion 63 99.86 Very High Very High Very High
Death 12 90.60 High High
Apoptosis 25 90.00 High High
Epilepsy 19 83.92 Quite High
Status Epilepticus 1 74.08 Quite High
Fetal Alcohol Syndrome 4 5.00 Very Low Very Low Very Low
Neurological Disease 2 5.00 Very Low Very Low Very Low
Cognitive Disorder 2 5.00 Very Low Very Low Very Low
Hyperalgesia 1 5.00 Very Low Very Low Very Low
Anxiety Disorder 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our findings indicate that primary culture from PTZ-induced seizure model triggers robust caspase-3 activation, release of cytochrome-c and decrease GABAB1R expression which has further decreasing effect on PKA expression level in hippocampal neurons of prenatal rat brain, while the co treatment of baclofen and phaclofen reverse the effects of PTZ and provide neuroprotection.
Positive_regulation (triggers) of Localization (release) of PKA in brain associated with convulsion
1) Confidence 0.28 Published 2009 Journal Mol Brain Section Body Doc Link PMC2706809 Disease Relevance 0.72 Pain Relevance 0.03

General Comments

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