INT275377

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Context Info
Confidence 0.04
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 2.93
Pain Relevance 1.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Htatsf1) nucleus (Htatsf1)
Anatomy Link Frequency
neuronal 2
Htatsf1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Analgesic 40 97.96 Very High Very High Very High
Endep 32 95.20 Very High Very High Very High
Morphine 28 94.60 High High
Gabapentin 28 94.20 High High
Cannabinoid receptor 12 93.44 High High
agonist 20 92.60 High High
Pain 68 85.20 High High
c fibre 20 85.04 High High
Peripheral nerve injury 12 81.44 Quite High
Neuropeptide 8 78.00 Quite High
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 436 100.00 Very High Very High Very High
Hypersensitivity 84 99.52 Very High Very High Very High
Injury 40 86.40 High High
Pain 48 85.20 High High
Nervous System Injury 32 80.56 Quite High
Anxiety Disorder 12 65.20 Quite High
Wallerian Degeneration 8 48.04 Quite Low
Neuropathic Pain 136 39.72 Quite Low
Apoptosis 36 24.88 Low Low
Nociception 4 18.24 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Alterations in non-neuronal cells in the DRG following perineural HIV-1 gp120
Positive_regulation (perineural) of HIV-1 in neuronal associated with acquired immune deficiency syndrome or hiv infection
1) Confidence 0.04 Published 2007 Journal Pain Section Body Doc Link PMC2706950 Disease Relevance 0.53 Pain Relevance 0.16
To assess the sensitivity of the perineural HIV-1 gp120 induced mechanical hypersensitivity to clinically efficacious analgesic compounds, we have evaluated the analgesic efficacy of amitriptyline, morphine, gabapentin and the cannabinoid receptor agonist, WIN-55,212-2, in our model.
Positive_regulation (induced) of HIV-1 associated with analgesic, hypersensitivity, morphine, cannabinoid receptor, agonist, acquired immune deficiency syndrome or hiv infection, endep and gabapentin
2) Confidence 0.04 Published 2007 Journal Pain Section Body Doc Link PMC2706950 Disease Relevance 0.85 Pain Relevance 0.80
Perineural HIV-1 gp120 is associated with increased ATF3, caspase-3 but not GAP-43 or c-Jun expression in the DRG
Positive_regulation (Perineural) of HIV-1 associated with acquired immune deficiency syndrome or hiv infection
3) Confidence 0.04 Published 2007 Journal Pain Section Body Doc Link PMC2706950 Disease Relevance 0.64 Pain Relevance 0.13
The effect of perineural HIV-1 gp120 on primary sensory neuronal phenotype
Positive_regulation (perineural) of HIV-1 in neuronal associated with acquired immune deficiency syndrome or hiv infection
4) Confidence 0.04 Published 2007 Journal Pain Section Body Doc Link PMC2706950 Disease Relevance 0.91 Pain Relevance 0.22

General Comments

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