INT275382

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Latest revision as of 10:16, 21 September 2012

Context Info
Confidence 0.30
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.26
Pain Relevance 0.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
satellite cell 2
Cd68 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 18 99.84 Very High Very High Very High
Pain 17 96.96 Very High Very High Very High
Thermal hyperalgesia 1 93.76 High High
Peripheral nerve injury 3 88.96 High High
calcitonin gene related peptide 6 85.96 High High
Inflammatory mediators 1 70.00 Quite High
Inflammatory response 4 60.68 Quite High
cytokine 9 54.92 Quite High
Hippocampus 22 36.40 Quite Low
Neuropathic pain 20 22.20 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 24 99.84 Very High Very High Very High
Pain 12 96.96 Very High Very High Very High
Apoptosis 29 94.40 High High
Hyperalgesia 1 93.76 High High
Nervous System Injury 8 88.96 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 109 82.64 Quite High
Neurodegenerative Disease 10 76.96 Quite High
Injury 13 76.08 Quite High
Congenital Anomalies 2 72.76 Quite High
Disease 36 69.36 Quite High

[edit] Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although pointing to a down-regulation of inflammation is the enhanced expression of CD68 a member of the family of neuroimmune regulatory proteins (NIRegs).
Positive_regulation (enhanced) of Gene_expression (expression) of CD68 associated with inflammation
1) Confidence 0.30 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2915993 Disease Relevance 0.94 Pain Relevance 0.18
However, the expression of galanin, NPY; the satellite cell marker, GFAP and the macrophage marker, CD68, did increase in the DRG, all of which are features of models of nerve-lesion associated pain (Ma and Bisby, 1998; Wynick et al., 2001).
Positive_regulation (increase) of Gene_expression (expression) of CD68 in satellite cell associated with pain
2) Confidence 0.21 Published 2007 Journal Pain Section Body Doc Link PMC2706950 Disease Relevance 1.32 Pain Relevance 0.40

[edit] General Comments

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