INT275842

Context Info Confidence 0.01 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.76 Pain Relevance 0

small molecule metabolic process (HPD) Golgi apparatus (HPD) endoplasmic reticulum (HPD) intracellular (Tlr2) cytoplasm (Tlr2) cytosol (HPD)

HPD (Homo sapiens) Tlr2 (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 12 43.12 cytokine 29 42.08 agonist 1 5.00 Angina 1 5.00 antagonist 1 5.00

Disease Link Frequency Relevance Heat Mycobacterial Infection 70 100.00 Infection 55 86.88 Latent Tuberculosis 6 50.00 INFLAMMATION 13 43.12 Lymphatic Filariasis 7 5.00 Worm Infection 4 5.00 Disease 4 5.00 Autoimmune Disease 2 5.00 Hypersensitivity 2 5.00 Cough 1 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Both baseline (Figure 1A) as well as PPD- (Figure 1B) and Mtb CFP-specific (Figure 1C) induction of TLR2 and 9 was significantly lower in PPD+Fil+ patients (TLR2: geometric mean [GM] of 0.7373 in PPD+Fil+ vs. 0.7973 in PPD+Fil?

PPD Positive_regulation (induction) of TLR2 associated with mycobacterial infection

1) Confidence 0.01 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2710006 Disease Relevance 0.76 Pain Relevance 0

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