INT275851

Context Info Confidence 0.01 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 1.96 Pain Relevance 1.83

nucleoplasm (PES1) intracellular (PES1) transmembrane transport (CP) cell proliferation (PES1) extracellular space (CP) extracellular region (CP)

Anatomy Link Frequency duct 1 PES1 (Homo sapiens) CP (Homo sapiens)

Pain Link Frequency Relevance Heat Chronic pancreatitis 55 100.00 Pain 20 100.00 Cholecystokinin 7 82.60 nud 1 62.72 Inflammation 2 61.80 Bile 9 47.64 fibrosis 9 5.00 alcohol 4 5.00 abdominal pain 2 5.00 antagonist 2 5.00

Disease Link Frequency Relevance Heat Pancreatitis 55 100.00 Pain 19 100.00 Disease 5 90.16 Dyspepsia 1 62.72 INFLAMMATION 2 61.80 Steatorrhea 17 60.80 Appetite Loss 9 52.12 Weight Gain 1 41.24 Cystic Fibrosis 9 5.00 Diabetes Mellitus 7 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Randomized controlled trials have suggested that non-enteric coated PES reduce pain in CP,25,26 whereas enteric coated forms are less beneficial.27–29 A meta-analysis did not support the use of PES for the relief of pain in all patients.30 In the above studies, however, the patients with idiopathic CP and patients with less advanced disease (“small duct CP”) achieved the greatest pain relief with PES.

PES Negative_regulation (reduce) of CP in duct associated with pain, disease and chronic pancreatitis

1) Confidence 0.01 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2710383 Disease Relevance 1.96 Pain Relevance 1.83

General Comments

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