INT275954

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Context Info
Confidence 0.54
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.75
Pain Relevance 0.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Lat) plasma membrane (Lat) intracellular (Lat)
Anatomy Link Frequency
platelets 2
Lat (Mus musculus)
Pain Link Frequency Relevance Heat
Paroxysmal extreme pain disorder 32 100.00 Very High Very High Very High
agonist 14 90.88 High High
sodium channel 9 68.24 Quite High
Pain 17 63.28 Quite High
Neuronal excitability 2 61.60 Quite High
dorsal root ganglion 31 60.72 Quite High
potassium channel 1 30.72 Quite Low
tetrodotoxin 11 5.00 Very Low Very Low Very Low
Action potential 10 5.00 Very Low Very Low Very Low
adenocard 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Somatoform Disorder 32 100.00 Very High Very High Very High
Sprains And Strains 45 94.92 High High
Cold Sores 89 93.96 High High
Erythermalgia 31 64.52 Quite High
Pain 20 63.28 Quite High
Ganglion Cysts 33 60.72 Quite High
Thrombosis 2 47.88 Quite Low
Hemorrhage 2 46.60 Quite Low
Increased Venous Pressure Under Development 7 30.32 Quite Low
Infection 11 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In theory, the breeding of mice that are deficient in both Gads and LAT is required to confirm a role for Gads in the regulation of LAT in that a similar level of inhibition should be seen in mice platelets deficient in LAT to those deficient in LAT and Gads.
Regulation (regulation) of LAT in platelets
1) Confidence 0.54 Published 2008 Journal Journal of Thrombosis and Haemostasis Section Body Doc Link PMC2710801 Disease Relevance 0 Pain Relevance 0
Several mechanisms may underlie the effect of PEPD mutations within the N-terminal part of the DIII/S4-S5 linker on NaV1.7 fast-inactivation: the contribution of residues within DIII- and DIV/S4-S5 linkers to the docking receptor for the fast-inactivation IFMT tetrapeptide [39-42], or predicted mutant-induced perturbation of the ?
Regulation (effect) of linker associated with paroxysmal extreme pain disorder
2) Confidence 0.44 Published 2010 Journal Mol Pain Section Body Doc Link PMC2876140 Disease Relevance 0.35 Pain Relevance 0.32
The differing dependency on LAT and SLP-76 in the GPVI and CLEC-2 signaling cascades could reflect either the presence of a LAT-like molecule in platelets or the presence of a LAT-independent pathway of recruitment of SLP-76 to the membrane.
Regulation (dependency) of LAT in platelets
3) Confidence 0.39 Published 2008 Journal Journal of Thrombosis and Haemostasis Section Body Doc Link PMC2710801 Disease Relevance 0 Pain Relevance 0.05
The fact that we can observe these epigenetic changes in the reactivation critical LAT 5?
Regulation (changes) of LAT 5
4) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2973973 Disease Relevance 0.40 Pain Relevance 0

General Comments

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