INT275996

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Context Info
Confidence 0.05
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.44
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

chromosome organization (Rpa1) nucleus (Rpa1) DNA binding (Rpa1)
cytoplasm (Rpa1)
Rpa1 (Mus musculus)
Pain Link Frequency Relevance Heat
depression 27 95.28 Very High Very High Very High
Central nervous system 6 57.36 Quite High
interneuron 3 55.96 Quite High
long-term potentiation 12 34.28 Quite Low
Dopamine 3 8.88 Low Low
gABA 33 5.00 Very Low Very Low Very Low
imagery 15 5.00 Very Low Very Low Very Low
Kinase C 3 5.00 Very Low Very Low Very Low
Serotonin 3 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Depression 27 95.28 Very High Very High Very High
Adhesions 6 79.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although calcineurin was not significantly involved in the Ca2+ threshold for RP induction, it is critical for the GABABR-mediated suppression of RP induction (Kawaguchi and Hirano, 2002).
Negative_regulation (suppression) of Positive_regulation (induction) of RP
1) Confidence 0.05 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2710870 Disease Relevance 0 Pain Relevance 0.03
Thus, RP seems to be induced by high-frequency excitatory inputs within a limited period and suppressed by tonic inhibitory inputs.
Negative_regulation (suppressed) of Positive_regulation (induced) of RP
2) Confidence 0.04 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2710870 Disease Relevance 0.44 Pain Relevance 0.18
It was suggested that GABABR suppresses the RP induction by reducing the amount of cAMP and the PKA activity by Gi-mediated inhibition of adenylyl cyclase (Kawaguchi and Hirano, 2000).
Negative_regulation (reducing) of Positive_regulation (induction) of RP
3) Confidence 0.04 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2710870 Disease Relevance 0 Pain Relevance 0

General Comments

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