INT276010

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Context Info
Confidence 0.06
First Reported 2009
Last Reported 2009
Negated 1
Speculated 4
Reported most in Body
Documents 1
Total Number 9
Disease Relevance 0.72
Pain Relevance 0.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

chromosome organization (Rpa1) nucleus (Rpa1) DNA binding (Rpa1)
cytoplasm (Rpa1)
Anatomy Link Frequency
inhibitory interneurons 2
Rpa1 (Mus musculus)
Pain Link Frequency Relevance Heat
depression 81 94.96 High High
gABA 99 94.48 High High
Pyramidal cell 9 86.64 High High
interneuron 9 84.28 Quite High
dopamine receptor 9 64.96 Quite High
Serotonin 9 63.36 Quite High
long-term potentiation 36 62.60 Quite High
imagery 45 61.48 Quite High
Glutamate receptor 9 60.32 Quite High
Central nervous system 18 51.20 Quite High
Disease Link Frequency Relevance Heat
Depression 81 94.96 High High
Adhesions 18 93.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These pathways might regulate the [Ca2+]i threshold for RP induction.
Spec (might) Regulation (regulate) of Positive_regulation (induction) of RP
1) Confidence 0.06 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2710870 Disease Relevance 0 Pain Relevance 0
M), did not affect the threshold for the RP induction (500 ms, 168±6%; 100 ms, 105±9%; 60 ms, 109±3%; 40 ms, 100±9%; 20 ms, 108±20%) (Figure 8E).
Neg (not) Regulation (affect) of Positive_regulation (induction) of RP
2) Confidence 0.06 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2710870 Disease Relevance 0 Pain Relevance 0
Next, we examined the threshold for RP induction.
Spec (examined) Regulation (threshold) of Spec (examined) Positive_regulation (induction) of RP
3) Confidence 0.04 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2710870 Disease Relevance 0 Pain Relevance 0.08
Using these conditioning stimulations, we examined the [Ca2+]i threshold for RP induction.
Spec (examined) Regulation (threshold) of Spec (examined) Positive_regulation (induction) of RP
4) Confidence 0.04 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2710870 Disease Relevance 0 Pain Relevance 0.12
Using the simulation model, we next attempted to address how the threshold for RP induction is determined.
Regulation (threshold) of Positive_regulation (induction) of RP
5) Confidence 0.04 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2710870 Disease Relevance 0 Pain Relevance 0
Thus, the induction of RP depends predominantly on the intensity rather than the duration of [Ca2+]i increase, whereas its suppression depends more strongly on the duration than on the intensity of GABABR activation.
Regulation (depends) of Positive_regulation (induction) of RP
6) Confidence 0.03 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2710870 Disease Relevance 0 Pain Relevance 0
Thus, RP induction might be regulated through spatio-temporally integrating multiple synaptic inputs from inhibitory interneurons, a climbing fiber, and parallel fibers, and signals arising from cell-adhesion molecules.
Spec (might) Regulation (regulated) of Positive_regulation (induction) of RP in inhibitory interneurons associated with adhesions
7) Confidence 0.03 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2710870 Disease Relevance 0.19 Pain Relevance 0.10
Feedforward and feedback loops in a network contribute to the nonlinear performance of the system, and there are such loops in the signaling cascades regulating the RP induction.
Regulation (regulating) of Positive_regulation (induction) of RP
8) Confidence 0.02 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2710870 Disease Relevance 0 Pain Relevance 0
A computational model of signaling cascades regulating RP induction was constructed incorporating our earlier results (Kawaguchi and Hirano, 2000, 2002), with some modifications (Figure 1).
Regulation (regulating) of Positive_regulation (induction) of RP
9) Confidence 0.02 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2710870 Disease Relevance 0.54 Pain Relevance 0.41

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