INT276331

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Context Info
Confidence 0.46
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 6.88
Pain Relevance 1.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (Il22ra1) cellular_component (Il22ra1) biological_process (Il22ra1)
Anatomy Link Frequency
lymphocytes 1
epithelial cells 1
Il22ra1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 73 98.56 Very High Very High Very High
rheumatoid arthritis 112 98.08 Very High Very High Very High
cytokine 94 93.80 High High
Arthritis 172 83.40 Quite High
Inflammatory response 9 82.88 Quite High
antagonist 5 53.60 Quite High
chemokine 19 19.44 Low Low
Crohn's disease 11 5.00 Very Low Very Low Very Low
corticosteroid 9 5.00 Very Low Very Low Very Low
metalloproteinase 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Anaplastic Large Cell Lymphoma 60 99.60 Very High Very High Very High
Cancer 276 99.40 Very High Very High Very High
INFLAMMATION 74 98.56 Very High Very High Very High
Rheumatoid Arthritis 118 98.08 Very High Very High Very High
Colitis 9 94.92 High High
Syndrome 32 91.20 High High
Malignant Neoplastic Disease 26 84.16 Quite High
T-cell Lymphoma 63 84.12 Quite High
Arthritis 138 83.40 Quite High
Multiple Sclerosis 14 82.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IL22 is expressed during chronic inflammation by Th17, natural killer (NK) and Dendritic (DC) cells [37] and acts on IL-22R subunit expressing (intestinal) epithelial cells to induce IL10 and acute phase protein production [38].
Gene_expression (expressing) of IL-22R in epithelial cells associated with inflammation
1) Confidence 0.46 Published 2010 Journal Cell Div Section Body Doc Link PMC2887830 Disease Relevance 0.60 Pain Relevance 0.31
IL-22R1 expression was also expressed in both the lining and the sublining layers of RA synovial tissues [29].
Gene_expression (expressed) of IL-22R1 associated with rheumatoid arthritis
2) Confidence 0.02 Published 2010 Journal Semin Immunopathol Section Body Doc Link PMC2836464 Disease Relevance 1.18 Pain Relevance 0.49
IL-22R1 expression was also expressed in both the lining and the sublining layers of RA synovial tissues [29].
Gene_expression (expression) of IL-22R1 associated with rheumatoid arthritis
3) Confidence 0.02 Published 2010 Journal Semin Immunopathol Section Body Doc Link PMC2836464 Disease Relevance 1.17 Pain Relevance 0.49
The expression of IL-22R1 in ALK(+)ALCL is aberrant, as this protein is absent in benign lymphocytes.
Gene_expression (expression) of IL-22R1 in lymphocytes associated with anaplastic large cell lymphoma
4) Confidence 0.01 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 1.29 Pain Relevance 0
Nucleophosmin (NPM)-ALK, the characteristic fusion gene oncoprotein expressed in ALK(+)ALCL, directly contributes to the aberrant expression of IL-22R1, as transfection of NPM-ALK in Jurkat cells induced IL-22R1 expression and IL-22-mediated STAT3 activation [18].
Gene_expression (expression) of IL-22R1 associated with anaplastic large cell lymphoma
5) Confidence 0.01 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 1.29 Pain Relevance 0.03
Nucleophosmin (NPM)-ALK, the characteristic fusion gene oncoprotein expressed in ALK(+)ALCL, directly contributes to the aberrant expression of IL-22R1, as transfection of NPM-ALK in Jurkat cells induced IL-22R1 expression and IL-22-mediated STAT3 activation [18].
Gene_expression (expression) of IL-22R1 associated with anaplastic large cell lymphoma
6) Confidence 0.01 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 1.34 Pain Relevance 0

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