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Context Info
Confidence 0.15
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 7
Disease Relevance 2.87
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (PIM1) plasma membrane (PIM1) nucleus (PIM1)
cell cycle (PIM1) transcription factor binding (PIM1) cytoplasm (PIM1)
PIM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
depression 4 64.92 Quite High
beta blocker 16 57.64 Quite High
Central nervous system 11 51.24 Quite High
addiction 4 21.56 Low Low
Analgesic 4 13.24 Low Low
cINOD 20 12.60 Low Low
tricyclic antidepressant 16 5.00 Very Low Very Low Very Low
chemokine 15 5.00 Very Low Very Low Very Low
corticosteroid 9 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Mantle-cell Lymphoma 99 99.78 Very High Very High Very High
Cancer 123 99.40 Very High Very High Very High
Lymphatic System Cancer 366 85.40 High High
Incontinence 4 67.36 Quite High
Disease 98 66.80 Quite High
Cognitive Disorder 4 66.64 Quite High
Depression 4 64.92 Quite High
Frailty 11 64.88 Quite High
Diffuse Large B-cell Lymphoma 168 63.00 Quite High
Delirium 4 62.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunohistochemical analysis of a cohort of 33 human MCL show that elevated expression of Pim-1 occurs in 42% of cases with elevated Pim-2 occurring in 9% of cases, all of which also express Pim-1.
Positive_regulation (elevated) of Gene_expression (expression) of Pim associated with mantle-cell lymphoma
1) Confidence 0.15 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 0.62 Pain Relevance 0
Immunohistochemical analysis of a cohort of 33 human MCL show that elevated expression of Pim-1 occurs in 42% of cases with elevated Pim-2 occurring in 9% of cases, all of which also express Pim-1.
Positive_regulation (occurs) of Gene_expression (expression) of Pim associated with mantle-cell lymphoma
2) Confidence 0.10 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 0.62 Pain Relevance 0
High levels of Pim expression, as occurs in tumors, active, but not inactive, Pim-1 or Pim-2 blocks the degradation of both p53 and Mdm2 in a manner that is independent of Mdm2 phosphorylation, leading to increased p53 levels and, proportionately, p53-dependent transactivation.
Positive_regulation (levels) of Gene_expression (expression) of Pim associated with cancer
3) Confidence 0.10 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 0.86 Pain Relevance 0
Risk factors for PIM prescribing
Positive_regulation (factors) of Gene_expression (prescribing) of PIM
4) Confidence 0.03 Published 2010 Journal Clin Interv Aging Section Body Doc Link PMC2854054 Disease Relevance 0.13 Pain Relevance 0
Numerous research studies have employed the Beers’ criteria to evaluate PIM prescribing and ADEs in the inpatient setting.
Positive_regulation (evaluate) of Gene_expression (prescribing) of PIM
5) Confidence 0.03 Published 2010 Journal Clin Interv Aging Section Body Doc Link PMC2854054 Disease Relevance 0.51 Pain Relevance 0.06
Strategic approaches to curtailing PIM prescribing
Positive_regulation (curtailing) of Gene_expression (prescribing) of PIM
6) Confidence 0.03 Published 2010 Journal Clin Interv Aging Section Body Doc Link PMC2854054 Disease Relevance 0.06 Pain Relevance 0.03
The use of a list of medications, such as the Beers’ criteria, as a sole measurement for PIM prescribing has disadvantages.
Positive_regulation (measurement) of Gene_expression (prescribing) of PIM
7) Confidence 0.03 Published 2010 Journal Clin Interv Aging Section Body Doc Link PMC2854054 Disease Relevance 0.07 Pain Relevance 0

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